BACKGROUND Conventional therapies for human papillomavirus (HPV) infection are often associated with unsatisfactory response rates and high recurrence rates. The use of a systemic agent may more effectively control the virus. OBJECTIVES To investigate the efficacy and safety of low dose oral isotretinoin in recalcitrant condylomata acuminata (RCA) of the cervix. METHODS Double blind placebo...

INTRODUCTION Central nervous system toxicity is a well-known side effect of isotretinoin treatment. The aim of this study was to establish the effects of isotretinoin on retinal nerve fiber layer (RNFL) thickness. MATERIALS AND METHODS Study subjects received oral isotretinoin treatment for nodulocystic acne. All patients underwent a detailed ophthalmologic examination including best-correcte...

OBJECTIVE To determine whether patients with moderate to severe acne who were treated with isotretinoin experienced significant increases in depressive symptoms over a 3- to 4-month period compared with patients who received conservative acne therapy. DESIGN Cohort study. SETTING Hospital-affiliated and community-based clinics in St Louis, Mo. PARTICIPANTS One hundred thirty-two subjects ...

Received May 11, 2012, Revised May 29, 2012, Accepted for publication June 3, 2012 Corresponding author: Kwang Hyun Cho, Department of Dermatology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea. Tel: 82-2-2072-2412, Fax: 82-2-742-7344, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons Attrib...

B Desvergne, and V Mooser. What is the problem and what is known about it so far? Isotretinoin (Accutane) is a vitamin A–like drug used to treat severe acne. It is a pill that is taken by mouth and is usually given to people who do not respond to treatment applied directly to the skin (topical). Isotretinoin may cause side effects, including birth defects, liver problems, hair loss, and increas...

INTRODUCTION Acne vulgaris is the most frequently diagnosed dermatosis in patients aged between 11 and 30. It is believed that it affects about 80% of persons in this age group or even, taking into account lesions of low intensity, 100% of young people. The role of cytokines in the pathogenesis of acne is not fully known. The TLR2 receptors play a role in the aetiology of acne. Stimulation of T...

The developmental neurotoxicity of phenytoin, isotretinoin, and methamphetamine has been reviewed to illustrate effects from both therapeutic and illicit drugs to which people are exposed and which either induce or show the potential for inducing learning disabilities following in utero exposure. In each case both human and experimental animal data are presented and compared where possible. The...

Purpose. Numerous ocular side effects have been reported with the use of systemic isotretinoin therapy. Herein, we presented two contact lens user patients who did not have contact lens intolerance during systemic isotretinoin therapy. Methods. 25-year-old male and 20-year-old female patients with severe acne vulgaris who were using highly wettable silicone hydrogel contact lenses which increas...

Oral isotretinoin, since its introduction more than 20 years ago, has been and still is the "gold standard" in the treatment of acne and its variants. This is the only approach to acne with the possibility of a permanent "cure" or long term remission. The role of isotretinoin has evolved with higher dosage schedules and use earlier in the course of the disease. The frequency of laboratory monit...