Allostery pervades macromolecular function and drives cooperative binding of ligands to macromolecules. To decipher the mechanisms of cooperative ligand binding it is necessary to define at a microscopic level the structural and thermodynamic consequences of binding of each ligand to its allosterically coupled site(s). However, dynamic sampling of alternative conformations (microstates) in allo...

As part of a systematic study devoted to the diagnostic of solar-like coronal structures in late-type stars, we have analyzed ROSAT/PSPC X-ray spectra of eight main sequence G-type stars in the solar neighborhood. We have tted the X-ray spectra adopting two diierent classes of models: the usual two-component isothermal models and the more physically meaningful hydrostatic loop models. The two-c...

In this contribution we present a simple and effective procedure to determine the average critical current of a tridimensional disordered Josephson junction array (3DDJJA). Using a contactless configuration we evaluate the average critical current and the typical width of the distribution through the analysis of the isothermal susceptibility response to the excitation field amplitude, χAC(h). A...

We introduce a counter-flow turbulent channel configuration, amenable to simulation and modeling. It has periodic streamwise spanwise boundaries isothermal no-slip walls. A tangent hyperbolic forcing function drives the flow in opposite directions on upper lower halves of channel, forming an antisymmetric mean shear velocity profile. Compared conventional flows, is inflectional maximum turbulen...

effects of ?-cyclodextrin, ?cd, on refolding of lysozyme was investigated at ph 12 employing isothermal titration calorimetry (itc) at 300k in 30mm tris buffer solution. ?cd was employed as an anti-aggregation agent and the heats obtained for lysozyme+?cd interactions are reported and analyzed in terms of the extended solvation model. it was indicated that there are two sets of identical and no...

poly(ethylene adipte) and poly(ethylene adipate)/silica nanocomposite (pead/sio2) containing 3 wt. % sio2  were prepared by an in situ method. the examinations on the non-isothermal crystallization kinetic behavior have been conducted by means of differential scanning calorimeter (dsc). the avrami, ozawa, and combined avrami and ozawa equations were applied to describe the crystallization kinet...

Dimerization process is essential for producing copolymers. The features of dimerization process like thermal-oxidative degradation should be well known to reach maximum efficiency and a superior reactor design. Also, the degradation mechanism of biodegradable polymers is important during sterilization processes. Thermal-oxidative degradation of PGA, PLLA, and their binary copolymers was invest...

We examine whether a cosmologically significant distribution of dark galaxy group or cluster-sized objects can have an optical depth for multiple imaging of distant background sources which is comparable to that from known galaxies while at the same time producing angular splittings of the same order of magnitude. Our purpose is to explore whether such objects could realistically account for so...

We report on an investigation of the SBS 1520+530 gravitational lens system. We have used archivalHubble Space Telescope (HST ) imaging,Keck spectroscopic data, andKeck adaptive optics (AO) imaging to study the lensing galaxy and its environment. The AO imaging has allowed us to fix the lens galaxy properties with a high degree of accuracy when performing the lens modeling, and the data indicat...

We described an electrochemical method to monitor in real-time the isothermal helicase-dependent amplification of nucleic acids. The principle of detection is simple and well-adapted to the development of portable, easy-to-use and inexpensive nucleic acids detection technologies. It consists of monitoring a decrease in the electrochemical current response of a reporter DNA intercalating redox p...