Polyhydroxyalkanoates (PHAs) are a biodegradable and biobased family of bacterial polyesters with different architectures. Among them, the poly-3-hydroxybutyrate (PHB) is one most conventional easily obtained by biotechnologies from bioresources. However, this thermoplastic polyester known since more than 50 years presents until now only very limited applications due to certain number drawbacks...

In the title compound, [Ni(C(38)H(38)N(10))](NO(3))(2)·2H(2)O, the Ni(II) ion is located on a crystallographic twofold rotation axis and is in a distorted octa-hedral coordination environment. The crystal structure is stablized by inter-molecular N-H⋯O and C-H⋯O hydrogen bonds, and weak C-H⋯π inter-actions. The O atoms of the unique nitrate ion are disordered over two sites with occupancies of ...

BACKGROUND Osteoporotic fractures are common and are associated with increased morbidity, mortality and health care costs. The most effective way to moderate increases in health care costs and the sickness and premature death associated with osteoporotic fractures, is to prevent osteoporosis. Several lines of evidence suggest that nitrates, drugs typically prescribed for the treatment of angina...

BACKGROUND Nitrates are one of the most commonly prescribed drug groups for cardiac disease, especially for angina pectoris and congestive heart failure. The chronic efficacy of nitrates is limited by the development of tolerance, which can be attenuated by use of sustained-release preparations or administration of regular-release preparations asymmetrically. OBJECTIVE To determine whether pa...

The effects of 15, 30, 60 and 120 mg of isosorbide dinitrate (ISDN) on systolic blood pressure (SBP) and heart rate (HR) were compared after acute oral administration and during sustained therapy four times daily with ISDN in six patients. After any given dose, plasma ISDN levels were higher during sustained therapy than during acute therapy. The average peak reduction in standing SBP occurred ...

Twelve patients with angina pectoris were evaluated in a single blind crossover study with respect to objective changes in exercise performance on the treadmill and subjective, clinical improvement on oral administration of propranolol, isosorbide dinitrate (ISD), and a combination of propranolol and ISD. Combined objective and subjective evaluations showed that nine of 12 patients improved on ...

Isosorbide mononitrate (ISMN) is effective in the short-term for decreasing systolic blood pressure, pulse pressure, and pulse wave reflection in patients with systolic hypertension. To determine whether tolerance negates the efficacy of this nitrate in the long-term, a placebo-controlled study was performed in which ISMN was withdrawn briefly in a group of patients (n=16) who had received exte...