An efficient synthesis of 2H-thiopyran derivatives via three-component reaction of alkyl propiolate, benzoyl isothiocyanate or its derivatives and alkyl bromides in the presence of triphenylphosphine in water at 80o C without using any catalyst in water is described. The method offers several advantages including high yields of products and an easy work-up procedure.

We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung adenoma formation induced by tobacco carcinogens in A/J mice at the post-initiation stage. The tumor-inhibitory activity by these compounds is linked with activation of activator protein and induction of apoptosis in lung tissues, suggesting th...

We read with interest the recent article by Batalla et al. on the use of hand hygiene and antisepsis products among health care professionals and the relationship between these products and hand eczema. While we are in full agreement with the central message of the article and the authors’ algorithm for the management of patients with intolerance to alcohol-based products, we would like to add ...

We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung adenoma formation induced by tobacco carcinogens in A/J mice at the postinitiation stage. The tumor-inhibitory activity by these compounds is linked with activation of activator protein and induction of apoptosis in lung tissues, suggesting tha...

NUMBER 1, SEPTEMBER, 1946 I. The Response of Hypodynamic Myocardium to Known Concentrations of Cardiac Glycosides. Wallace F. White and William T. Salter 1 II. Comparison of Pressor Action of Aliphatic Amines. E. E. Swanson and K. K. Chen 10 III. Digitalis. III. The Relationship Between the Potency and Baljet Reaction of the Glycosides of Digitalis. Frederick K. Bell and John C. Krantz, Jr 14 I...

BACKGROUND Many disinfectants have been used clinically in both single and combination applications, but there have been few studies on disinfective power according to sterilization sequence when using a combination of disinfectants. The purpose of this study was to evaluate the disinfective power of a combination of 70% isopropyl alcohol and 10% povidone-iodine (PVP-I) according to sterilizati...

The comparative in vitro skin permeability of diclofenac sodium through excised mouse skin from different common pharmaceutical vehicles like castor oil, olive oil, arachis oil, liquid paraffin, white soft paraffin melt, 3% sodium carboxymethyl cellulose (CMC) aqueous gel and isopropyl myristate (IPM), excluding other excipients was evaluated. Significantly (p < 0.05) higher flux of diclofenac ...

Isopropyl methanesulfonate (IPMS) is the most potent genotoxic compound among methanesulfonic acid esters. The genotoxic potential of alkyl sulfonate esters is believed to be due to their alkylating ability of the O6 position of guanine. Understanding the primary repair pathway activated in response to IPMS-induced DNA damage is important to profile the genotoxic potential of IPMS. In the prese...