INTRODUCTION The magnitude of current resistance to antituberculosis drugs in Spain is unknown. The objective of this study is to describe resistance to first-line antituberculosis drugs and determine the associated factors. METHODS Prospective multicenter study of adult tuberculosis patients with positive Mycobacterium tuberculosis culture and antibiogram including first-line drugs in 32 hos...

Isoniazid is one of the most commonly used drugs to treat tuberculosis. Its administration is associated with a high incidence of hepatotoxicity. The aim of this study was to establish the protective effects of taurine against cytotoxicity induced by isoniazid and its suspected toxic metabolite hydrazine in isolated rat hepatocytes by measuring reactive oxygen species (ROS) formation, lipid per...

OBJECTIVES A novel and simple method to synthesize antitubercular-protein conjugate by solid phase synthesis was developed employing a carboxypolystyrene resin. The aim was to covalently bind a drug with antitubercular activity, isoniazid, to a biomacromolecule, gelatin, widely used in the pharmaceutical, cosmetic and food industry. METHODS Calorimetric and (1) H NMR analyses were performed t...

This paper describes a case of an acute and fatal isoniazid-induced hepatotoxicity and provides a review of the literature. A 65-year-old female diagnosed with latent Mycobacterium tuberculosis infection was receiving oral isoniazid 300 mg daily. She was admitted to the hospital for epigastric and right sided flank pain of one-week duration. Laboratory results and imaging confirmed hepatitis. A...

Isoniazid given orally readily and rapidly diffuses into the cerebrospinal fluid in health and disease (Fletcher, I952, 1953) and probably, also, gains access to tubercle bacilli within the cells. Adequate bacterio-static level of the isoniazid in the cerebrospinal fluid was found in both lower and higher doses. Throughout the illness Ritchie (I953) showed that isoniazid is more diffusible in t...

OBJECTIVE To determine whether initial isoniazid resistance is associated with death during the treatment of tuberculous meningitis. DESIGN Retrospective cohort study. SETTING National Tuberculosis Surveillance System at the Centers for Disease Control in the United States. PARTICIPANTS Patients with a clinical diagnosis of tuberculous meningitis, reported to the National Tuberculosis Sur...

An urgent task is the development of new implantation materials with a prolonged medicinal effect for treatment extrapulmonary form tuberculosis. The purpose this investigation was to obtain an material based on mesh polyurethane anti-tuberculosis drug isoniazid, study release isoniazid from polymer, biodegradation such materials, as well analyze cellular reactions their in body experimental an...

Abstract Background Ending the global tuberculosis (TB) epidemic requires a focus on treating individuals with latent TB infection (LTBI) to prevent future cases. Promising trials of shorter regimens have shown them be effective as preventative treatment, however there is paucity data self-administered treatment completion rates. This pilot trial assessed completion, adherence, safety and feasi...