The clinical results recently reported by the Edmonton group in recipients of allogeneic islet grafts, all of whom achieved at least temporary insulin independence, has rekindled interest in transplantation of islets of Langerhans as a means to cure diabetes. Long-term islet graft survival has been achieved in a non-human primate pre-clinical model with a protocol of T-cell signaling blockade u...

Abstract Purpose Artificial organs might serve as alternative solutions for whole organ transplantation. Decellularization of a liver provides non-immunogenic matrix with the advantage three afferent systems, portal vein, hepatic artery and bile duct. This study aims to evaluate recellularization rat livers islets Langerhans via duct vein comparison different perfusion routes. Methods Rat were ...

This review discusses the prospects for treatment of insulin-dependent diabetes mellitus. The use insulin-producing cells various origins is relevant and may in future replace radical transplantation whole pancreas individual islets Langerhans. authors have paid attention to peculiarities obtaining stem by directed differentiation proliferation fractions cells, as well their clinical practice. ...

OBJECTIVE — Success after islet transplantation can be defined in terms of insulin independence, C-peptide secretion, or glycemic control. These measures are interdependent and all need to be considered in evaluating -cell function after islet transplantation. For the current study, a composite -score was developed that provides an integrated measure of -cell function success after islet transp...

Introduction: Islet transplantation has become a promising treatment for type I diabetes mellitus due to recent success since the development of the Edmonton Protocol. Islet culture prior to transplantation is standard practice in several clinical islet programs. High-density islet culture is desirable because it reduces space and handling requirements during culture, but it exacerbates oxygen ...

(Received for publication, April 25, 1959) It is no doubt that diabetes mellitus occurs as a result of deficiency in insulin due to hypofunction of the pancreatic Langerhans' islet cells, but no one nowardays would call diabetes mellitus a disease caused by a mere change in the Langerhans' islets. At present, diabetes mellitus is considered to be due to disturbance of some endocrine organsl)2)3...