Introduction Liver function is affected during ischemia/reperfusion (IR). The current state of knowledge about liver aging processes during IR is incomplete. We evaluated the effects of aging on liver structure and function under IR conditions. Material and methods Animals were divided into control (C-2) and ischemia/reperfusion (IR-2) groups of young rats (2-4 months old) and C-12 and IR-12 ...

BACKGROUND AND PURPOSE Cells die by one of two mechanisms, necrosis or programmed cell death. Necrosis has been implicated in stroke and occurs when the cytoplasmic membrane is compromised. Programmed cell death requires protein synthesis and often involves endonucleolytic cleavage of the cellular DNA. We assessed the potential contribution of programmed cell death to ischemia-induced neuronal ...

Background and Purpose: Cells die by one of two mechanisms, necrosis or programmed cell death. Necrosis has been implicated in stroke and occurs when the cytoplasmic membrane is compromised. Programmed cell death requires protein synthesis and often involves endonucleolytic cleavage of the cellular DNA. We assessed the potential contribution of programmed cell death to ischemia-induced neuronal...

OBJECTIVE To determine cerebrospinal fluid levels of interleukin-6 and tumor necrosis factor-alpha in full-term infants with hypoxic-ischemic encephalopathy, comparing with control infants. METHODS Controlled, prospective study, performed between July 1999 and October 2001 with two groups of full-term newborns: 20 controls with no sepsis and/or meningitis and Apgar score > or =9 at first and ...

OBJECTIVE Ischemic preconditioning reduces infarct size and improves hemodynamic function. Unstable angina may be a clinical analogue to ischemic preconditioning, and involve activation of gene programs. We hypothesized that preceding unstable angina and/or ischemic preconditioning activated genes regulated by nuclear factor kappa B (NFkappaB) or hypoxia-inducible factor 1 alpha in parallel to ...

Heart failure is a clinical syndrome of ischemic and non ischemic etiology. Imaging plays a major part in diagnosing its cause, course, and prognosis. In the ischemic heart, positron emission tomography (PET), by, for example, assessing myocardial perfusion and glucose metabolism, and magnetic resonance imaging (MRI), by evaluating myocardial function, myocardial necrosis, and/or inotropic cont...

From rodents to primates, transient global brain ischemia is a well known cause of delayed neuronal death of the vulnerable neurons including cornu Ammonis 1 (CA1) pyramidal cells of the hippocampus. Previous reports using the rodent experimental paradigm indicated that apoptosis is a main contributor to such ischemic neuronal death. In primates, however, the detailed molecular mechanism of isc...

Ischemic stroke (cerebral infarction) is a common clinical disease of ischemic necrosis or softening localized brain tissue, which belongs to in traditional Chinese medicine (TCM). In recent years, its incidence rate has gradually increased, the age onset tends be younger, and seriously affects quality life patients with cerebral infarction. TCM rehabilitation one effective methods improve symp...

Tumor suppressor gene p53 and its aggregate have been found to be involved in many angiogenesis-related pathways. We explored the possible aggregation formation mechanisms commonly occur after ischemic stroke, such as hypoxia presence of reactive oxygen species (ROS). The angiogenic pathways involving mainly nucleus or cytoplasm, with one exception that occurs mitochondria. Considering high mit...