Kidney disease is associated with a wide variety of metabolic abnormalities that accompany the uremic state and dialysis dependence. These include altered L-carnitine homeostasis, mitochondrial dysfunctions, in fatty acid metabolism. essential for metabolism proper function. Deficiency kidney caused by reduction endogenous renal synthesis, impaired metabolism, lower intake due to dietary restri...

CYP3A4-inhibitors can potentiate the hypotensive effect of calcium-channel blockers. However, insufficient attention to such drug interactions may result in serious adverse reactions. A 71-year-old hypertensive man prescribed nifedipine was hospitalized for infectious endophthalmitis. Antimicrobial therapy with voriconazole lowered the blood pressure, and then clarithromycin further lowered it ...

Since the discovery of microRNAs, ample research has been conducted to elucidate their involvement in an array of (patho)physiological conditions. Ischemia reperfusion injury is a major problem in kidney transplantation and its mechanism is still not fully known, nor is there an effective therapy. Furthermore, no biomarker is available to specifically measure (ischemic) damage after kidney tran...

Acute renal failure (ARF) is often the consequence of an ischemia-reperfusion injury (IRI) and associated with high mortality. Warm ischemia (WI) is a crucial factor of tissue damage, and tissue destruction led by ischemia-reperfusion (I/R) can impact the early and long-term functional outcome. Trimetazidine (TMZ) is an anti-ischemic drug. Previously, we already verified its protective effect o...

Endotoxemia (LPS) can exacerbate ischemic tubular injury and acute renal failure (ARF). The present study tested the following hypothesis: that acute ischemic damage sensitizes the kidney to LPS-mediated TNF-alpha generation, a process that can worsen inflammation and cytotoxicity. CD-1 mice underwent 15 min of unilateral renal ischemia. LPS (10 mg/kg iv), or its vehicle, was injected either 45...

Huen SC, Moeckel GW, Cantley LG. Macrophage-specific deletion of transforming growth factor1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury. Am J Physiol Renal Physiol 305: F477–F484, 2013. First published June 12, 2013; doi:10.1152/ajprenal.00624.2012.—Macrophage infiltration is a prominent feature of the innate immune response to kidney injury. The per...

Resume. The search for new drugs with cytoprotective and anti-ischemic activity is an urgent task of modern pharmacology. These properties are necessary the complex protection renal parenchyma during organ preservation operations (renal resection), most often carried out in conditions thermal ischemia. Only combined use highly effective skill operating surgeon can prevent development acute inju...

While unilateral nephrectomy (UNx) is suggested to protect against ischemia-reperfusion injury (IRI) in the remaining kidney, the mechanisms underlying this protection remain to be elucidated. In this study, functional MRI was employed in a renal IRI rat model to reveal global and regional changes in renal filtration, perfusion, oxygenation and sodium handling, and microarray and pathway analys...

conclusions vancomycin nephrotoxicity is common but usually reversible and has readily manageable adverse effect. urine kim-1 was not more accurate than serum or urine creatinine in detecting vancomycin nephrotoxicity in our study population. results thirteen out of the 52 recruited patients (25%) developed nephrotoxicity, with a mean ± standard deviation onset of 11.46 ± 7.56 days. furosemide ...