Cats subjected to coronary artery occlusion were used to study the effect of methylprednisolone on the release of lysosomal acid hydrolases and creatine phosphokinase (CPK) from ischemic myocardial tissue. Plasma CPK activity was increased significantly 2 hours after occlusion and increased eightfold 5 hours after ligation in vehicle-treated cats. Intravenous administration of methylprednisolon...

The best-known function of the serine protease tissue-type plasminogen activator (tPA) is as a thrombolytic enzyme. However, it is also found in structures of the brain that are highly vulnerable to hypoxia-induced cell death, where its association with neuronal survival is poorly understood. Here, we have demonstrated that hippocampal areas of the mouse brain lacking tPA activity are more vuln...

Occlusion of the circumflex coronary artery induced a profound redistribution in ischemic rabbit myocardium of several lysosomal acid hydrolases, including cathepsin D, B-acetylglycosaminidase, and acid phosphatase. 30-45 min after ligation non-sedimentable cathepsin D activity rose from 36% of the total activity to 42-48%, and in immunohistochemical preparations cathepsin D appeared to have di...

In the management of acute ischemic stroke, guideline adherence is often suboptimal, particularly for intravenous thrombolysis or anticoagulation for atrial fibrillation. We sought to improve stroke care quality via a collaborative model, the Breakthrough Series (BTS)-Stroke activity, in a nationwide, multi-center activity in Taiwan. A BTS Collaborative, a short-term learning system for a large...

background: stroke is the most common neurologic disease and an important cause of morbidity and mortality. headache is an initial presenting feature of ischemic stroke and sometimes preceedes the development of stroke and thus, provides an opportunity for offering preventive measures. the aim of the present study was to determine the association of new onset headache with stroke. methods: a to...

our aim was to report techniques and our experience in one-stage angioplasty and stenting of ostium of left common carotid and left internal carotid arteries in an octogenarian man with transient ischemic attack, who was completely recovered from neurologic insults short time after the procedure. an 81-year-old man presented with a transient ischemic attack. neurologic examination showed left s...

introduction: ischemic stroke is amongst the top four causes of mortality and the leading cause of disability in the world. the aim of this study was to evaluate the efficacy of a high dose memantine on neurological function of patients with ischemic stroke.methods: in a randomized, 2 armed, open-label study, patients with mild to moderate cerebral thromboembolic event (ctee) who admitted to im...

background: stroke is one of the most frequent causes of death and disability worldwide and has significant clinical and socioeconomic impact. hyperlipidemia and inflammation play major roles in atherothrombosis and in stroke. this study is conducted to compare the high sensitive c-reactive protein (hs-crp) levels and the lipid profile parameters between stroke patients and control group and de...

conclusions the lower levels of sugar in crushed fingers compared to healthy fingers can help to diagnose gangrene in crushed fingers. objectives the current study aimed to compare the blood sugar (bs) levels measured by the glucometer in healthy and crushed fingers to predict gangrene in patients referred to 15 khordad hospital in tehran, iran. methods this cohort study was conducted on 265 pa...