نتایج جستجو برای: ischemiareperfusion injury pyramidal neurons

تعداد نتایج: 484663  

2015
Kyungjoon Park Hwon Heo Ma Eum Han Kyuhyun Choi Jee Hyun Yi Shin Jung Kang Yunhee Kim Kwon Ki Soon Shin

Neuronal loss caused by neurodegenerative diseases, traumatic brain injury and stroke results in cognitive dysfunctioning. Implantation of neural stem/precursor cells (NPCs) can improve the brain function by replacing lost neurons. Proper synaptic integration following neuronal differentiation of implanted cells is believed to be a prerequisite for the functional recovery. In the present study,...

Journal: :iranian biomedical journal 0
پریچهر پاس بخش parichehr pasbakhsh مهدی مهدی زاده mehdi mehdizadeh ژیلا بهزادی gila behzadi

background: mediodorsal (md) thalamic nucleus, which is considered to take place between extra pyramidal and limbic feedback circuit, receives projective fibers from ventrolateral neurons of reticular part of substantia nigra (snr). in order to better understand the influence and chemical reaction of these fibers upon md nucleus, the morphology and synaptology of them were examined in the prese...

Journal: :Annals of neurology 2000
N Villeneuve Y Ben-Ari G L Holmes J L Gaiarsa

We investigated the effects of repeated early-life seizures induced by flurothyl inhalation on intrinsic membrane properties of hippocampal pyramidal neurons from young rats (postnatal day 15-20). Intracellular recordings of CA1 and CA3 pyramidal neurons from flurothyl-treated and control rats revealed no significant differences in resting membrane potential, input resistance, membrane time con...

2017
Jennifer I. Luebke

A key challenge in cortical neuroscience is to gain a comprehensive understanding of how pyramidal neuron heterogeneity across different areas and species underlies the functional specialization of individual neurons, networks, and areas. Comparative studies have been important in this endeavor, providing data relevant to the question of which of the many inherent properties of individual pyram...

Journal: :Cerebral cortex 2004
Véronique M André Jorge Flores-Hernández Carlos Cepeda Amaal J Starling Snow Nguyen Mary Kay Lobo Harry V Vinters Michael S Levine Gary W Mathern

The subunit composition of glutamate receptors affects their functional properties, and could contribute to abnormal electrophysiology in pediatric cortical dysplasia (CD). We examined electrophysiological responses and subunit assembly of N-methyl-D-aspartate (NMDA) receptors in acutely dissociated normal-appearing pyramidal and cytomegalic neurons from CD tissue and normal-appearing pyramidal...

2017
Zahid Padamsey Lindsay McGuinness Nigel J. Emptage

A growing body of evidence suggests that lysosomes, which have traditionally been regarded as degradative organelles, can function as Ca2+ stores, regulated by the second messenger nicotinic acid adenine dinucleotide phosphate (NAADP). We previously demonstrated that in hippocampal pyramidal neurons, activity-dependent Ca2+ release from these stores triggers fusion of the lysosome with the plas...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Mika Ushimaru Yasuo Kawaguchi

UNLABELLED Slow-wave oscillations, the predominant brain rhythm during sleep, are composed of Up/Down cycles. Depolarizing Up-states involve activity in layer 5 (L5) of the neocortex, but it is unknown how diverse subtypes of neurons within L5 participate in generating and maintaining Up-states. Here we compare the in vivo firing patterns of corticopontine (CPn) pyramidal cells, crossed-cortico...

2013
Rogier B. Poorthuis Bernard Bloem Benita Schak Jordi Wester Christiaan P. J. de Kock Huibert D. Mansvelder

Acetylcholine signaling through nicotinic receptors (nAChRs) in the prefrontal cortex (PFC) is crucial for attention. Nicotinic AChRs are expressed on glutamatergic inputs to layer V (LV) cells and on LV interneurons and LVI pyramidal neurons. Whether PFC layers are activated by nAChRs to a similar extent or whether there is layer-specific activation is not known. Here, we investigate nAChR mod...

Journal: :Tropical Journal of Pharmaceutical Research 2023

Purpose: To evaluate the protective effect, effective time window, and mechanism of protection sevoflurane post-conditioning late on heart muscle ischemiareperfusion (I/R) lesion in isolated rat heart.Methods: Langendorff perfusion model was established Sprague-Dawley (SD) rats. After 15 min stabilization, rats were assigned to 10 groups, based treatments given: control group (TTC), I/R group, ...

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