نتایج جستجو برای: ischemia reperfusion
تعداد نتایج: 94631 فیلتر نتایج به سال:
Background: Renal ischemia reperfusion (RIR) injury is a common clinical syndrome that affects renal function and significantly increases morbidity and mortality. Hydrogen sulfide (H2S) is an endogenously gaseous mediator that exhibits many cytoprotective effects. Recently, studies have shown that H2S have opposite effects in different doses. Therefore, in the current study we investigated the ...
Nitric oxide (NO) is involved in the pathogenesis of cerebral ischemic injury. Here, we investigated effects aging on NO production during ischemia-reperfusion (IR). Male Wister rats (WRs) were assigned to 12-month-old (older; n = 5) and 3-month-old (younger; 7) groups. Similarly, male spontaneous hypertensive (SHRs) allocated 6) 8) After anesthesia, their was monitored using vivo microdialysis...
introduction: stroke is the third important reason of death in adults and an important cause of adult disability. previous studies suggest that tgf-alpha can induce neurogenesis after stroke. here in, we studied neurogenesis effects of the tgf-alpha on subventricular zone following ischemia-reperfusion. male wistar rats (250-300 g) were divided into ischemia and treatment groups. after inductio...
ischemia reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. ischemia reperfusion induces cell death and endemic reaction that is one of the most important clinical problems with acute renal failure and renal transplantation. in this study, the effect of pentoxifylline on rat kidney function and cell injury followi...
Introduction: Metformin (MET) as an oral antidiabetic drug has pleiotropic effects such as antioxidative and neuroprotective properties. In the current study we aimed to investigate the probable effects of Pretreatment MET therapy in global ischemia-reperfusion in rats. Materials and Methods: In this study, 40 male Wistar rats (200-220 g) were used. Animals were randomly divided into four g...
Introduction: Ischemic Preconditioning (IPC) is the phenomen that happens on the heart by one or several short periods of ischemia followed by reperfusion that improve the postischemic recovery of mechanical function. Ischemic preconditioning (IPC) may protect the heart from ischemia reperfusion injury by nitric oxide formation. This study investigated the effect of ischemic preconditioni...
Introduction: Hyperoxia is an easy access preconditioner which attracts the researcher to use it in the clinic. Drug dependence is a widespread prevalence among different societies and one of the confounding factors in many diseases. Among different drugs, morphine dependence has shown preconditioning effects. According to both widespread phenomenon of drug addiction and use of hyperoxia in the...
Background and Aim: Testicular torsion is a urological emergency that leads to testicular tissue damage and infertility. In recent years, several studies have been conducted on the antioxidant properties of nanoparticles. The aim of this study was to investigate the effects of Diamond nanoparticles on the apoptosis in rats with testicular ischemia / reperfusion. Methods: 48 adult rats aged 20 ...
BACKGROUND AND PURPOSE Superoxide anion radicals (O2*-) are implicated in ischemia/reperfusion injury, although a direct relationship has not been elucidated. Recently, a specific method of hydroethidine (HEt) oxidation by O2*- was developed to detect O2*- production in a variety of experimental brain injury models. To clarify the role of O2*- in the mechanism of ischemia/reperfusion, we invest...
Objective(s):Global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the possible neuroprotective effects of the ethanol extract of Cyperus rotundus (EECR) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory. Materials and Methods: Treatment ...
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