Introduction: Diabetic kidney disease (DKD) is a major global cause of end-stage-kidney disease. In view its ongoing risk progression, the search for better biomarkers and treatment led to discovery microRNAs which regulate gene expression post-translationally. Recently, we reported trend upregulation miR-145-5p in sera type 2 diabetic patients with macroalbuminuria selected Malaysian populatio...

Generally, most miRNAs that were up-regulated during differentiation promoted adipogenesis, but our research indicated that up-regulation of miR-145 in porcine preadipocytes did not promote but inhibit adipogenesis. In this study, miR-145 was significantly up-regulated during porcine dedifferentiated fat (DFAT) cells differentiation. In miR-145 overexpressed DFAT cells, adipogenesis was inhibit...

MicroRNAs (miRNAs) have been demonstrated to serve an important role in diverse biological processes and cancer progression. Downregulation of microRNA-497 (miR-497) has been observed in human colorectal cancer (CRC) tissues, but the function of miR-497 in CRC has not been well investigated. In the present study, it was demonstrated that expression of miR-497 was significantly downregulated in ...

Purpose: To investigate the genetic polymorphisms that may contribute to the worsening of insulin resistance in type 2 diabetes mellitus (T2DM) with severe or acute hyperglycemia. Methods: This is a prospective cohort study involving 156 T2DM patients with severe or acute hyperglycemia from all medical wards of the National University of Malaysia Medical Centre (UKMMC) that were placed on insul...

We searched for shocked carbon chain chemistry (SCCC) sources with C$_3$S abundances surpassing those of HC$_5$N towards the dark cloud L1251, using Effelsberg telescope at K-band (18 -- 26\,GHz). L1251-1 and L1251-3 are identified as most promising SCCC sources. The two harbor young stellar objects. conducted mapping observations L1251-A, western tail $\lambda$ $\sim$3\,mm PMO 13.7 m NRO 45 te...

Insulin receptor substrate (IRS) harbors proteins such as IRS1, IRS2, IRS3, IRS4, IRS5 and IRS6. These key proteins act as vital downstream regulators in the insulin signaling pathway. However, little is known about the evolutionary relationship among the IRS family members. This study explores the potential to depict the evolutionary relationship among the IRS family using bioinformatics, algo...