The aim of this article is to review the pathophysiology and clinical role of serotonin receptor modulators used in the treatment of irritable bowel syndrome. Serotonin is an important monoamine neurotransmitter that plays a key role in the initiation of peristaltic and secretory refl exes, and in modulation of visceral sensations. Several serotonin receptor subtypes have been characterized, of...

Irritable bowel syndrome (IBS) is a condition characterized by abdominal pain, bloating, flatus, and altered bowel habits. The role of dietary components in inducing IBS symptoms is difficult to explore. To date, foods are not considered a cause but rather symptom-triggering factors. Particular interest has been given to the so-called FODMAPs (fermentable oligo-, di-, and monosaccharides and po...

Irritable bowel syndrome (IBS) is a common cause of recurrent abdominal pain (RAP) in children and can be a debilitating experience for both child and family. Organic causes of RAP symptoms such as celiac and inflammatory bowel diseases should be excluded before a diagnosis of IBS is made. Treatment consists of dietary manipulation, drugs, and stress management. Newer therapies may offer better...

introduction: dyspepsia, gastroesophageal reflux disease (gerd) and irritable bowel syndrome (ibs) are the most common gastrointestinal diseases. their prevalence is 18-30%, 25-30% and 10-15% in western communities and 8-14%, 3-7% and 3-5% in eastern countries, respectively. there is no adequate data about their prevalence in our country. the aim of this study is to determine the prevalence of ...

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, significantly reducing life quality patients and negatively affecting public health in general. For a long period time, this pathology has been studied exclusively from view motility disorder visceral hypersensitivity. At same there more evidence that significant role disease pathogenesis can be play...

The following guidelines, based on a comprehensive review,1 were developed as an update to assist the physician in the clinical understanding, diagnosis, and management of patients with irritable bowel syndrome (IBS). They may also be of assistance to allied health care professionals, the pharmaceutical industry, and regulatory agencies. IBS is a functional bowel disorder characterized by sympt...

BACKGROUND/AIMS A limited number of studies are available regarding the long-term natural history of post-infectious irritable bowel syndrome (PI-IBS). We aimed to investigate the long-term clinical course of PI-IBS. METHODS A prospective cohort study was conducted from a 2001 shigellosis outbreak in a Korean hospital with about 2000 employees. A cohort of 124 hospital employees who were infe...

INTRODUCTION Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder characterized by symptoms, such as abdominal pain, bloating, diarrhea, and constipation, that are not attributable to structural or biochemical abnormalities (1). Although several conceptual models of IBS pathogenesis have been suggested, including visceral hypersensitivity, abnormal intestinal motility, ...

BACKGROUND Irritable bowel syndrome (IBS) is more common in patients with ulcerative colitis (UC) than expected. The prevalence of IBS in patients with UC with longstanding disease is not known. We investigated the prevalence of IBS-like symptoms in patients with UC in remission and longstanding disease in comparison to control subjects. METHODS Sixty-eight patients with UC and 33 patients wi...

BACKGROUND The aims of this study were to evaluate the effect and mechanism of a traditional Chinese medicine formula: Tongxieyaofang (TXYF) on Rats with Post Infectious Irritable Bowel Syndrome (PI-IBS). METHODS SD male rats in adult were used to model PI-IBS and treated with TXYF at three dosage for 14 consecutive days, and then visceral sensation and the frequency of stool in PI-IBS rats w...