Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the literature regarding statin-associated mood/behavioral changes remains limited. We sought to elicit information germane to natural history and characteristics of central nervous system/behavioral changes in apparent connection with statin and/or cholesterol-lowering drug use, and delineate mechanisms that may ...

BACKGROUND The irritant effect of some insecticides can cause a proportion of mosquitoes to leave the sprayed rooms before acquiring a lethal dose, so the repeated contact al sub-lethal dose may lead to extent the resistance. METHODS Larvae and pupae of Culex pipiens complex were collected in mass from open canals of waste water in capital city Tehran and reared to obtain the first generation...

Characteristics of the subjective symptomatology of asthma were explored within a group of 100 asthma inpatients. Patients rated the relative frequency with which 77 symptom adjectives were associated with asthma attacks. Key cluster analysis of the full set of 77 adjectives identified 5 symptom clusters: Two Mood clusters, Panic-Fear and Irritability, describe affective states concomitant with...

There is some discussion concerning the phenomenology of pediatric bipolar disorder. This condition is marked by irritability and sudden mood swings, and has no specific diagnostic criteria. Disagreement is even greater for bipolar disorder in preschool age. We report the case of a child of four years and nine months with diagnosis of bipolar disorder not otherwise specified. Predominant sympto...

We evaluated the efficacy and safety of aripiprazole in the treatment of irritability in children and adolescents (6-17 years) with autism spectrum disorder (ASD) in a randomized, double-blind, placebo-controlled 8-week study in Japan. Patients received flexibly dosed aripiprazole (1-15 mg/day) or placebo. Ninety-two patients were randomized to placebo (n = 45) or aripiprazole (n = 47). Aripipr...

Outcome Measures Parentor child-rated severity of itch; parentor child-rated severity of sleep disturbance, irritability and skin appearance; emollient use (adherence); attitudes to eczema and emollient therapy. Results 50 subjects completed the intervention and follow-up. 20% had previously been shown how to apply emollient creams by a GP or nurse but only 10% were applying them correctly. The...