Biofilm growth on the implant surface is the number one cause of the failure of the implants. Biofilms on implant surfaces are hard to eliminate by antibiotics due to the protection offered by the exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and immune cells. Application of metals in nanoscale is considered to resolve biofilm formation. Here we...

Water soluble and biocompatible iron oxide nanoparticles coated with poly(aspartic acid) (PAsp), poly(asparagines) (PAsn), poly(2-hydroxy-ethyl L-aspartamide) (PHEA), and poly-α,β-(N-2-dimethylaminoethyl L-aspartamide) (PDMAEA) were prepared by hydrophobic interaction between hydrophobic iron oxide nanoparticles and each amphiphilic poly(amino acid)s graft polymer. The octadecyl side chain graf...

Iron oxide nanoparticles are a useful diagnostic contrast agent and have great potential for therapeutic applications. Multiple emerging diagnostic and therapeutic applications and the numerous versatile parameters of the nanoparticle platform require a robust biological model for characterization and assessment. Here we investigate the use of iron oxide nanoparticles that target tumor vasculat...

Submit Manuscript | http://medcraveonline.com treating these and other bacterial infections currently exist; there is still an essential need for new and improved approaches for bacterial destruction. Nanomedicine is one approach to overcome challenges of conventional drug delivery systems based on the development and fabrication of nanostructures. Various types of nanoparticulate systems have ...

BACKGROUND Iron oxide nanoparticles are of considerable interest because of their use in magnetic recording tape, ferrofluid, magnetic resonance imaging, drug delivery, and treatment of cancer. The specific morphology of nanoparticles confers an ability to load, carry, and release different types of drugs. METHODS AND RESULTS We synthesized superparamagnetic nanoparticles containing pure iron...

OBJECTIVES To validate the feasibility of labeling Clostridium novyi-NT (C.novyi-NT) anaerobes with iron-oxide nanoparticles for magnetic resonance imaging (MRI) and demonstrate the potential to use MRI to visualize intra-tumoral delivery of these iron-oxide labeled C.novyi-NT during percutaneous injection procedures. MATERIALS AND METHODS All studies were approved by IACUC. C.novyi-NT were l...

In order to enhance the utilization of inorganic nanoparticles in biological systems, it is important to develop a fundamental understanding of the influence they have on cellular health and function. Experiments were conducted to test silica, silica/iron oxide, and gold nanoparticles for their effects on the growth and activity of Escherichia coli (E. coli). Transmission electron microscopy (T...

The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely in the recent years due to the multiple applications of these nanomaterials, mainly in domains like cancer. The aim of the present study was: (i) to develop biocompatible colloidal suspensions based on magnetic iron oxide nanoparticles as future theranostic tools for skin pathology and (ii) to test their effects i...

iron oxide nanoparticles were synthesized by coprecipitation method using ammonia as precipitation agent. most researchers usually add ammonia into the iron salt solution but in this work the salt solution drop wise has been added to the ammonia and the new obtained results were compared with those of other researches. magnetic properties of nanoparticles were measured by vsm. the effect of rea...

Superparamagnetic iron oxide nanoparticles produce changes in the surrounding microscopic magnetic field. A method for generating contrast based on the application of an adiabatic preparation pulse and the failure of the adiabatic condition surrounding the nanoparticles is introduced in this article. Images were obtained in the presence and absence of an adiabatic preparation pulse and the diff...