sis usually involve chaotropic agents such as guanidinium chloride and (or) detergents for the dissociation of iron at an acidic pH from transferrin. Reduction is achieved with various reducing compounds such as ascorbic acid, hydroxylamine, thioglycolic acid, and others. Among these, ascorbic acid is unique in its property not only to reduce but also to chelate iron. This property appears to b...

The equilibrium problems, characterized by recurring end-points, involved in the reaction of iron (III) with iodide make the batch iodometric determination of iron (III) unsuitable. Since the flow injection determination does not require attainment of steady state either for mixing of reagents or for the chemical reaction, the iodometric determination has been accurately and precisely performed...

The cadmium content of crystallized horse spleen ferritin, usually about 2% by weight without special treatment, can be substantially decreased by prolonged dialysis against certain chelating agents, chaotropic ions, or weakly reducing anions. For example, neutral bisulphite buffer (2M) removed 95% of the bound cadmium of crystallization without affecting the iron content, and may thus be valua...

Synovial iron deposition associated with rheumatoid disease may result in the production of highly reactive oxygen free radicals, leading to tissue damage. This chain of events can be interrupted by iron chelation. Families of strong iron (III) chelators have been tested for their iron scavenging properties in vitro and their effects assessed in vivo using a rat model of inflammation. All the c...

This study was conducted to investigate the effect of external iron status and arsenic species on chelant-enhanced iron bioavailability and arsenic uptake. Rice seedlings (Oryza sativa L.) were used as model plant, and were grown in artificially contaminated sandy soils irrigated with Murashige and Skoog (MS) culture solution. Arsenate uptake in roots and shoots of rice seedlings were affected ...

Several efforts have been made to detoxify the effect of metals once they are administered in the human body. Chelation is considered the best method used so far. Medicinal treatment of acute and chronic metal toxicity is provided by chelating agents. Chelation is one of the chemical functions that take place in the bodies of almost all living organisms. It is a process by which plants and anim...

I N veal production, the color of the fresh meat is an important factor affecting its quality. The consumer considers that the light pink color of the carcass, which is associated with the feeding of milk, will reflect a specific taste. The paleness of the muscle tissue is actually developed by an exclusive milk feeding and results from a state of anemia due to the low iron content of the milk ...

Iron chelators for the treatment of malaria have proven therapeutic activity in vitro and in vivo in both humans and mice, but their clinical use is limited by the unsuitable absorption and pharmacokinetic properties of the few available iron chelators. FBS0701, (S)3"-(HO)-desazadesferrithiocin-polyether [DADFT-PE], is an oral iron chelator currently in Phase 2 human studies for the treatment o...