Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC  chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered immune responses. Deletion of 32 base pai...

Species identification is fundamentally important within the fields of conservation, biology, biogeography and ecology. Salvia species are herbaceous, biennial or annual, strongly aromatic. Inter-Simple sequence repeats (ISSR) molecular markers were used for evaluate genetic diversity relationship analysis 30 species. Ten selected ISSR primers amplified 116 loci, respectively, which all polymor...

Background: HLA genes are highly polymorphic and certain alleles are frequent only in specific populations. Therefore, HLA is a unique tool for studying the genetic relationship between different populations. Iranians are ethnically diverse people and one of the major ethnic groups in Iran is Lur population inhabiting along the central and southern parts of Zagros Chain Mountain. Objectives: Ge...

Background: Anthropological studies based on highly polymorphic HLA genes pro-vide useful information for bone marrow donor registry, forensic medicine, disease as-sociation studies, as well as designing peptide vaccines against tumors, and infectious or autoimmune diseases. Objective: This study was designed to investigate the genetic relationship of Iranian Arabs and Jews using HLA-class II g...

aim : the aim of this study is to evaluate the polymorphism in bax gene and its association with some clinical pathology traits in gastric cancer.   background : gastric cancer is considered as the fourth most common cancer in the north and northwest of iran. bcl2 family has a key role in regulation of apoptosis, and any changes in the expression of bcl2 lead to cancer. patients and methods : b...

the human mdr1 gene encodes for a p-glycoprotein (pgp), which acts as an efflux pump that transports a large variety of substrates from the inside of cells to the outside until protection against xenobiotics. the g2677t/a polymorphism in exon 21 is associated with pgp expression and function in humans. the present study was aimed to determine the frequencies of this polymorphism in a healthy po...

This paper introduces the concept of a dynamic key infrastructure for Grid. It utilises the properties of Identity-based Cryptography (IBC) to simplify key management techniques used in current Public Key Infrastructure (PKI) settings for Grid. This approach can offer greater simplicity, flexibility, and enhanced computation trade-offs.

BACKGROUND Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an important negative regulator of Tcell responses. The -1722TC polymorphism of the CTLA-4 gene may be associated with systemic lupus erythematosus (SLE) risk, but related results from previous studies have been inconsistent. We carried out a metaanalysis to assess this association more precisely. METHODS A systematic search t...