Both 5-HT and the 9 amino acid neuropeptide SCPb modulate 3 ionic currents in B15, enhancing a voltage-dependent inward sodium current, decreasing an outward potassium current and increasing an inward rectifying potassium current. In contrast, FMRFamide decreases a voltage-dependent inward sodium current and increases an outward potassium current. We have also investigated the roles of several ...

Ionic fluxes in Na channels of myelinated axons show ionic competition, block, and deviations from simple flux independence. These phenomena are particularly evident when external Na+ ions are replaced by other permeant or impermeant ions. The observed currents require new flux equations not based on the concepts of free diffusion. A specific permeability model for the Na channel is developed f...

Omelchenko, Alexander, Ron Bouchard, Sabin Shurraw, Michael Trac, Mark Hnatowich, and Larry V. Hryshko. Frequencydependent regulation of cardiac Na /Ca exchanger. Am J Physiol Heart Circ Physiol 289: H1594–H1603, 2005. First published June 10, 2005; doi:10.1152/ajpheart.01094.2004.—The activity of the cardiac Na /Ca exchanger (NCX1.1) undergoes continuous modulation during the contraction-relax...

The peptide 0~-agatoxin-IIIA (co-Aga-IIIA) blocks ionic current through L-type Ca channels in guinea pig atrial cells without affecting the associated gating currents, c0-Aga-IIIA permits the study of L-type Ca channel ionic and gating currents under nearly identical ionic conditions. Under conditions that isolate L-type Ca channel currents, 0~-Aga-IIIA blocks all ionic current during a test pu...

A B S TR ACT Ionic fluxes in Na channels of myelinated axons show ionic competition, block, and deviations from simple flux independence. These phenomena are particularly evident when external Na + ions are replaced by other permeant or impermeant ions. The observed currents require new flux equations not based on the concepts of free diffusion. A specific permeability model for the Na channel ...

The activity of the cardiac Na +-Ca 2+ exchanger (NCX1.1) undergoes continuous modulation during the contraction/relaxation cycle due to the accompanying changes in the electrochemical gradients for Na + and Ca 2+. In addition, NCX1.1 activity is also modulated via secondary, ionic regulatory mechanisms mediated by Na + and Ca 2+. In an effort to evaluate how ionic regulation influences exchang...

Ionic footbaths are currently being used as a way to assist the body in eliminating harmful substances such as heavy metals. The current study examined whether whole blood levels of heavy metals declined in individuals receiving ionic foot bath sessions in conjunction with meditation and nutritional supplementation. A non-experimental design with no control group was used. Thirty-one participan...

  While the effect of changes of stimulus waveform (quasitrapezoidal and rectangular current pulses) on nerve activation is clear, but there is no evidence on the effect of quasitrapezoidal pulses on ionic currents of cellular membrane. In the present study, the effect of depolarizing quasi-trapezoidal current pulses, in comparison with that of depolarizing rectangular current pulses, on firing...