Introduction: Human embryonic stem cells (hESCs) are pluripotent cells that can proliferate and differentiate to many cell types. Their electrophysiological properties have not yet been chracterzed. In this study, the passive properties (such as resting membrane potential, input resistance and capacitance) and the contribution of delayed rectifier K+ channel currents to the membrane conducta...

Microbiological impedance devices are routinely used by food and manufacturing industries, and public health agencies to measure microbiological growth. Factors contributing to increases and decreases in capacitance at the culture medium-electrode interface are poorly understood. To objectively evaluate the effects of temperature, cell density and medium conductivity on capacitance, admittance ...

Serotonin (5-HT) selectively excites subpopulations of pyramidal neurons in the neocortex via activation of 5-HT2A (2A) receptors coupled to Gq subtype G-protein alpha subunits. Gq-mediated excitatory responses have been attributed primarily to suppression of potassium conductances, including those mediated by KV7 potassium channels (i.e., the M-current), or activation of non-specific cation co...

Dear Sir: In his recent letter to you, Dr. Mullins suggests that the evidence on squid axon membrane conductances said to be compatible with the notion of two independent ionic conductances for Na and K "is not at present compelling." We certainly agree with this and furthermore would point out that we do not yet see any experiment which could help us choose definitively between a single channe...

We report the integration of inorganic nanotubes into metal-oxide-solution field effect transistors (FETs) which exhibit rapid field effect modulation of ionic conductance. Surface functionalization, analogous to doping in semiconductors, can switch the nanofluidic transistors from p-type to ambipolar and n-type field effect transistors. Transient study reveals the kinetics of field effect modu...

Electrolyte transport through an array of 20 nm wide, 20 microm long SiO(2) nanofluidic transistors is described. At sufficiently low ionic strength, the Debye screening length exceeds the channel width, and ion transport is limited by the negatively charged channel surfaces. At source-drain biases >5 V, the current exhibits a sharp, nonlinear increase, with a 20-50-fold conductance enhancement...

We report a nanofluidic transistor based on a metal-oxide-solution (MOSol) system that is similar to a metal-oxide-semiconductor field-effect transistor (MOSFET). Using a combination of fluorescence and electrical measurements, we demonstrate that gate voltage modulates the concentration of ions and molecules in the channel and controls the ionic conductance. Our results illustrate the efficacy...

Abstract This paper presents a novel approach to estimate major ion concentrations in estuaries from known specific conductance. Assuming two-source conservative mixing at steady state, we propose an extension of the Practical Salinity Scale 1978 ions and total dissolved solids as functions conductivity ratio, which is ratio sample seawater conductivity. We employ extensive salinity data set th...