The integration of a trapped ion mobility spectrometer (TIMS) with a mass spectrometer (MS) for complementary fast, gas-phase mobility separation prior to mass analysis (TIMS-MS) is described. The ion transmission and mobility separation are discussed as a function of the ion source condition, bath gas velocity, analysis scan speed, RF ion confinement, and downstream ion optical conditions. TIM...

In recent years, sequence-defined oligomers (SDOs) gained increasing interest due to their perfectly controlled molecular structure, thus providing defined properties. order tune the properties, different functionalities need be incorporated into and chain tacticity needs controlled. Beside synthesis of SDOs, suitable methods found analyze structure. this work, exhibiting an alternating or bloc...

Highly functionalised ruthenium(II) tris-bipyridine receptor 1 which acts as a selective sensor for equine cytochrome c (cyt c) is shown to destabilise the native protein conformation by around 25 °C. Receptors 2 and 3 do not exert this effect confirming the behaviour is a specific effect of molecular recognition between 1 and cyt c, whilst the absence of a destabilising effect on 60% acetylate...

In the second part of this study, a systematic comparison was made between two ion fragmentation acquisition modes, namely data-independent (DIA) and DIA with mobility spectrometry (IMS) technology. These approaches were applied to analysis 192 doping agents in urine. Group I included 102 compounds such as stimulants, diuretics, narcotics, β2-agonists, while II contained 90 steroids, glucocorti...

Ion mobility spectrometers (IMS) are small, lightweight, extremely robust devices with low power requirements, no moving parts, no absolute requirement for gases or vacuums, that can be operated at ambient temperatures and pressures, and yet are capable of measuring vapour phase concentrations of organic chemicals at very low levels (sub-mug/l). IMS are capable of analysing complex mixtures and...

Here, we present proof of principle studies to demonstrate how the product ions associated with ion mobility peaks obtained from a High Kinetic Energy-Ion Mobility Spectrometer (HiKE-IMS) measurement volatile can be identified using Proton Transfer Reaction/Selective Reagent Ion-Time-of-Flight-Mass (PTR/SRI-ToF-MS) when operating both instruments at same reduced electric field value and similar...

This paper describes total determination of aflatoxins B1 and B2 in pistachio samples using corona discharge ion mobility spectrometry (IMS). A new injection port was designed to introduce liquid samples into the IMS. Using this port, the liquid solvent (methanol) containing standard aflatoxins or an extracted sample was directly introduced into the injection port. Calibration curves resulting ...

Ion-mobility spectrometry (IMS) in conjunction with radioactive ionization sources has been employed for field-portable applications for the past two decades. Recently, electrospray ionization (ESI) sources have been shown as a viable ionization source with IMS instruments, enabling the analysis of many nonvolatile compounds. Introduction of a liquid-sheath-flow ESI source enabled the direct an...

The output signal generated by detectors used in ion mobility spectrometry (IMS) is a time-dependent, small ionic current. To be able to take full advantage of information contained in this signal, adequate procedures of signal processing need to be utilized. Methods of spectrum filtration, peak separation, base-line correction as well as one- and two-dimensional integration applied in quantita...