BACKGROUND AND OBJECTIVES Extracellular volume (ECV) is the fluid contained in all noncellular compartments of the body and is a quantity tightly controlled by the kidney. Thus, there is a strong link between ECV and kidney function. DESIGN, SETTING, PARTICIPANTS & MEASUREMENTS The Chronic Kidney Disease in Children (CKiD) study uses injected iohexol to obtain direct measures of GFR. Direct c...

We aimed to determine the characteristic adverse events (AEs) of iodinated contrast media (IOCM) and to compare the safety profiles of different IOCM. This study used the database of AEs reports submitted by healthcare professionals from 15 Regional Pharmacovigilance Centers between June 24, 2009 and December 31, 2010 in Korea. All reports of IOCM, including iopromide, iohexol, iopamidol, iomep...

The Schwartz formula was devised in the mid-1970s to estimate GFR in children. Recent data suggest that this formula currently overestimates GFR as measured by plasma disappearance of iohexol, likely a result of a change in methods used to measure creatinine. Here, we developed equations to estimate GFR using data from the baseline visits of 349 children (aged 1 to 16 yr) in the Chronic Kidney ...

The use of MDRD-eGFR to diagnose Chronic Kidney Disease (CKD) is based on the assumption that the algorithm will minimize the influence of age, gender and ethnicity that is observed in S-Creatinine concentration and thus allow a single cut-off at which further diagnostic and therapeutic actions should be considered. This hypothesis is tested in a retrospective analysis of outpatients (N=93,404)...

OBJECTIVE Increased glomerular filtration rate (GFR), also called hyperfiltration, is a proposed mechanism for renal injury in diabetes. The causes of hyperfiltration in individuals without diabetes are largely unknown, including the possible role of borderline hyperglycemia. We assessed whether impaired fasting glucose (IFG; 5.6-6.9 mmol/L), elevated HbA1c, or hyperinsulinemia are associated w...

Studies that used prolonged contrast media infusion in canine arteries have generated controversy regarding the arrhythmogenic potential of low osmolarity, nonionic contrast agents. In order to establish the relative safety of these agents in the more typical setting of bolus injections, 4 ml intracoronary bolus injections of Hypaque-76 (n = 54), Iohexol-350 (n = 51), and Iohexol-140 (n = 51) w...