A series of N,N-diethyl-3-substituted-2-(4-methylphenylsulfonamido)alkanamides (8a-k) and their arylsulfonamide precursors (7a-k) have been synthesized via facile approach. The chemical structures of the synthesized compounds were confirmed by analytical data and spectroscopic means. The in vitro antibacterial screening of these compounds along with streptomycin, showed N,N-diethyl-2-(4-methylp...

Acetylene carboxylates and an acetylene phosphonate reacted with N-protected (S)-2-(diazoacetyl)pyrrolidines ((S)-diazoprolines) to give optically active bis-heterocyclic pyrazole derivatives in a regioselective [3+2] cycloaddition. The reactions occurred at 60 °C in THF solution in the absence of a catalyst. However, diethyl ethynylphosphonate reacted significantly slower than the carboxylates...

Preparation of 2-Amino-2-Methyl-1 ,3Propandiol-Thymolphthalein Monophosphate (AMPD-TMP) Place 5 g (4.27 mmol) of magnesium thymolphthalein monophosphate (Eastman Kodak, Rochester, N. Y. 14650) in a 500-ml Erlenmeyer flask and add 100 ml of 2 mol/ liter HC1. Stir vigorously until the magnesium salt is well dispersed, add 100 ml of diethyl ether and continue stirring until a uniform suspension is...

of arresting rate ± S.E.) had settled on the control filter paper. These results and observations made clear that the MeOH extract of C. japonica strongly disturbed the A. vuigare isopods and made them move to the filter paper containing only water, indicating that the extract contained a repellent(s) against the isopod species. The crude MeOH extract suspended in water was successively extract...

in this study the anticonvulsant effect of two dihydropyridine derivatives [diethyl -1,4- dihydro -2,6- dimethyl -4-(4- fluoro benzyl-2- methylthio -5- imidazolyl)-3,5- pyridine dicarboxilat ( a ) and diethyl -1,4- dihydro -2,6- diethyl -4-(4- fluoro benzyl-2- methylthio -5- imidazolyl)-3,5- pyridine dicarboxilat ( b )] by pentylenetetrazole (ptz) and electroshock in mice was evaluated. the lat...

The insertion of a -NO2 group onto the corrole framework represents a key step for subsequent synthetic manipulation of the macrocycle based on the chemical versatility of such a functionality. Here we report results of the investigation of a copper 3-NO2-triarylcorrolate in nucleophilic aromatic substitution reactions with "active" methylene carbanions, namely diethyl malonate and diethyl 2-ch...

The title compound, C(15)H(22)BrN(3)O(2), consists of a pyridine ring with a bromine atom in the para position and two diethyl-amide groups in the ortho positions of the ring. Despite the positions of the three substituents on the pyridine ring, the mol-ecule does not exhibit either local or crystallographic twofold symmetry as the two diethyl-amido units exhibit significantly different N(py)-C...

A novel cyclization reaction of ethenetricarboxylate derivative aromatic compounds in the presence of various Lewis acids gave benzo-annulated cyclic compounds such as oxindole and benzofuran derivatives via Friedel-Crafts intramolecular Michael addition in high yields. For example, the reaction of diethyl 2-[(N-methyl-N-phenylcarbamoyl)methylene]malonate (1a) in the presence of ZnCl2 at room t...

In the title compound, [RhH(C74H68O8P2)(C18H15P)(CO)]·3C4H10O, the CHP3 coordination set at the Rh(I) ion is arranged in a distorted trigonal-bipyramidal geometry with the P atoms adopting equatorial coordination sites and the C atom of the carbonyl ligand as well as the H atom adopting the axial sites. The asymmetric unit contains two very similar mol-ecules of the rhodium complex, two half-oc...