The object of this paper is to establish certain generalized fractional integration and differentiation involving generalized Mittag-Leffler function defined by Salim and Faraj [25]. The considered generalized fractional calculus operators contain the Appell's function $F_3$ [2, p.224] as kernel and are introduced by Saigo and Maeda [23]. The Marichev-Saigo-Maeda fractional calculus operators a...