Working memory--including simple maintenance of information as well as manipulation of maintained information--has been long associated with lateral prefrontal cortex (PFC). More recently, evidence has pointed to an important role for posterior parietal cortex (PPC) in supporting working-memory processes as well. While explanations have emerged as to the nature of parietal involvement in workin...

The diagnosis of primary HIV-1 infection (PHI) is often missed and requires a high index of suspicion and a thorough knowledge of laboratory methods. We report the case of a young promiscuous male who presented with fever, rash and neurological symptoms 8 weeks after unprotected sexual exposure. Clinical and laboratory investigations showed the presence of leucopenia and thrombocytopenia with e...

This review summarizes the knowledge regarding ergonomics and musculoskeletal disorders and the association with computer work. Amodel of musculoskeletal disorders and computer work is proposed and the evidence and implications of the model together with issues for future research is discussed. The model emphasizes the associations between work organization, psychosocial factors and mental stre...

BACKGROUND The purpose of this study was to determine the clinicopathologic predictors of residual disease in patients with high-grade cervical intraepithelial neoplasia (CIN) and margin involvement after initial conization. METHODS Data from 145 patients who underwent subsequent surgery for high-grade CIN with positive margins were retrospectively analyzed. RESULTS After subsequent surgery...

Does awareness depend on attention? This is a fundamental issue for understanding the relationship of attention and awareness, yet previous research provided mixed results. Here, I describe new research that shows that the effects of attention on awareness depend on the level of perceptual load in the attended task. Awareness reports in both the inattentional blindness and change blindness para...

This review summarizes the knowledge regarding ergonomics and musculoskeletal disorders and the association with computer work. Amodel of musculoskeletal disorders and computer work is proposed and the evidence and implications of the model together with issues for future research is discussed. The model emphasizes the associations between work organization, psychosocial factors and mental stre...

Neutrophil extracellular traps (NETs) were initially described as an antimicrobial mechanism of neutrophils. Over the last decade, several lines of evidence support the involvement of NETs in a plethora of pathological conditions. Clinical and experimental data indicate that NET release constitutes a shared mechanism, which is involved in a different degree in various manifestations of non-infe...

Viral infections cause substantial morbidity and mortality in transplant patients. Quantifying viral loads is widely appreciated as a direct means to diagnose and monitor the course of viral infections. Recent studies indicate that the kinetics of viral load changes rather than single viral load measurements better correlate with organ involvement. In this Review, we will summarise the current ...

A long-standing theoretical debate concerns the involvement of principled reasoning versus relatively automatic intuitive-emotional processing in moral cognition. To address this, we investigated whether the mental models formed during story comprehension contain a moral dimension and whether this process is affected by cognitive load. A total of 72 participants read stories about fictional cha...

Although recent neuroimaging studies suggest that prefrontal cortex (PFC) is involved in working memory (WM), the relationship between PFC activity and memory load has not yet been well-described in humans. Here we use functional magnetic resonance imaging (fMRI) to probe PFC activity during a sequential letter task in which memory load was varied in an incremental fashion. In all nine subjects...