The Tuberculosis Centre of Research Excellence (TB-CRE) received $2.5 million of funding from the National Health and Medical Research Council (NHMRC) over a 5 year period (2013—2017). The TB-CRE is a multi-disciplinary centre that supports world-class research to improve coordination between and strengthen existing research initiatives in Australia on public health interventions, epidemiologic...

Urine is a complex fluid containing proteins, cells, nucleic acids, and a variety of extracellular vesicles. In the current issue of JASN, Hiemstra et al. demonstrate that exosomes, a specific type of extracellular vesicle, have antibacterial activity that could mediate host resistance to urinary tract infection (UTI). Given that UTI is themost commonhumanbacterial infection (around 150 million...

Some of the earliest case reports describing individual patients afflicted with cancer can be traced all the way back to the papyrus records of Ancient Egyptian medicine of approximately 1600 B.C.. Throughout the centuries physicians have continued the practice of writing case reports. Case reporting has provided significant advances in the knowledge of cancer on several fronts. It is without q...

Metabolomics uses high-resolution mass spectrometry to provide a chemical fingerprint of thousands of metabolites present in cells, tissues or body fluids. Such metabolic phenotyping has been successfully used to study various biologic processes and disease states. High-resolution metabolomics can shed new light on the intricacies of host-parasite interactions in each stage of the Plasmodium li...

Spectacular novel principles in medicine can definitely not originate from physicians, because they have become addicted to a dogmatized guideline-dictated medicine, based on firm belief in a study concept for “scientific studies.” It needs recognition that the medical methodology in several areas have not developed beyond external technical influence. The reason for this widely unrecognized ca...

With the increased reliance on the Internet, digital piracy is a hot topic that is receiving substantial interest. And while most studies concentrate on understanding piracy in developed countries, few studies have been done in developing countries. In order to fill in this gap, this study reports on an experiment to deter/prevent digital piracy behavior in an Arab and a Middle Eastern country....

Tuberculosis (TB), a chronic infectious disease mainly caused by the tubercle bacillus Mycobacterium tuberculosis, is one of the world's deadliest diseases that has afflicted humanity since ancient times. Although the number of people falling ill with TB each year is declining, its incidence in many developing countries is still a major cause of concern. Upon invading host cells by phagocytosis...