Background: To determine the incidence of an abnormal glucose tolerance test in patients with recurrent spontaneous abortion and whether metformin would safely reduce the rate of first trimester spontaneous abortions in patients without polycystic ovary syndrome (PCOS) as well as with PCOS and an abnormal glucose tolerance test. Materials and Methods: Patients with a history of recurrent sponta...

The interpretation of oral glucose tolerance tests is complicated by varying individual rates of absorption from the intestinal tract. Intravenous tests eliminate the absorption factor, but there is evidence that they may be less sensitive than oral tests in detecting impaired tolerance (Moyer and Womack, 1950). It was considered that a galactose tolerance test performed in parallel with a gluc...

The intravenous glucose tolerance test (I.V.G.T.T.) was used to diagnose chemical diabetes during pregnancy in 180 women, 50 of whom subsequently received chlorpropamide therapy in a daily dosage of 100 mg; the remainder had no drug therapy.Preliminary work showed the I.V.G.T.T. to be reproducible in the second and third trimesters but not in the puerperium in normal pregnancy. Though intraveno...