Introduction. The frequency of intraocular metastases is 64–67 % all metastatic tumors eye, with the choroid being mainly affected (88–90.7 %). In majority cases, are localized in central regions fundus (in 80 between equator and macular zone) and, characterized by rapid growth symptoms increase. There practically no information literature about choroidal foloww-up during polychemotherapy. stud...

purpose : to compare intraocular pressure (iop) readings measured by the ocular response analyzer (ora) with those measured by the goldmann applanation tonometer (gat) in keratoconic eyes following penetrating keratoplasty (pkp) and evaluate the influence of anatomical and biomechanical properties of the grafts on the iop measurements methods : in this cross-sectional study conducted on 45 kera...

Genomic studies of the pediatric ocular tumor retinoblastoma are paving the way for development of targeted therapies. Robust model systems such as orthotopic xenografts are necessary for testing such therapeutics. One system involves bioluminescence imaging of luciferase-expressing human retinoblastoma cells injected into the vitreous of newborn rat eyes. Although used for several drug studies...

Although the anterior chamber of the eye expresses immune privilege, some ocular tumors succumb to immune rejection. Previous studies demonstrated that adenovirus-induced tumors, adenovirus type 5 early region 1 (Ad5E1), underwent immune rejection following transplantation into the anterior chamber of syngeneic mice. Intraocular tumor rejection required CD4(+) T cells, but did not require the f...

Imatinib mesylate (IM) is a compound that inhibits both BCR-ABL tyrosine kinase and c-kit receptors. Tyrosine kinases are important in cellular signaling and mediate major cellular processes such as proliferation, differentiation, apoptosis, attachment, and migration. Twenty-six albino rabbits were injected with 1 × 10(6) human uveal melanoma (UM) cells (92.1) into the suprachoroidal space. Ani...

BACKGROUND AND OBJECTIVE Uveal melanoma is the most common primary intraocular cancer; however, the molecular features that predict response to therapy are poorly understood. Our objective was to determine whether gene expression profiling (GEP) is associated with rate of tumor regression after I-125 plaque brachytherapy for uveal melanoma. PATIENTS AND METHODS Retrospective review of 138 pat...

To generate animal models of retinoblastoma that closely resemble metastatic and nonmetastatic human disease for the purposes of examining tumor biology and of developing alternate treatments, human retinoblastoma cell lines were injected into the vitreal cavities of immunodeficient mice. Two reproducible animal models with contrasting biologic behavior analogous to human retinoblastoma have be...

Paciente com háptica da lente intraocular de peça única, na câmara anterior, tocando o seio camerular pressão 40mmHg. O implante única anterior não é recomendado,() devido a complicações que podem causar, como aumento intraocular, fechamento do ângulo camerular, dispersão pigmento, hemorragia, problemas refração, entre outros. Na literatura, descrevemos alternativa três peças no sulco ciliar ap...