background: bone marrow mesenchymal stem cells (bmscs) are the key to regenerative wound healing. mscs have spatial memory and respond to local environment. the goal of this study was to evaluate the use of systemic and intralesional transplantation of bmscs for regeneration of oral mucosa in an in vivo dog model. materials and methods: transplantation of undifferentiated green fluorescent prot...

salivary mucocele is a common lesion derived from minor salivary glands with various surgical or non-surgical treatment modalities. to evaluate the effect of a highly potent corticosteroid (dexamethasone) in the management of salivary mucocele, we performed intralesional injection of dexamethasone in nine patients with labial mucocele. complete healing of lesions observed in seven of nine patie...

background: leishmaniasis is a complex disease which presents as visceral, cutaneous and mucocutaneous forms. the current treatment options for this infection are very limited and the immunological state of the host appears to play an important role in the efficacy of the treatment. immunostimulation through immune response activating agents such as imiquimod is another rational approach for th...

background: to evaluate immunotherapy against canine visceral leishmaniasis, leishmania ma­jor antigen and heat-killed mycobacterium vaccae (srl172) were used as stimulators of immune de­fense mechanisms and the results were compared with standard chemotherapy meglumine antimoni­ate. methods: nineteen mongrel dogs aging 1-3 years old were used in this experiment. infection was carried out in 15...

INTRODUCTION Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in vivo by 300-700 fold has been intensely investigated. CASE PRESENTATION Keratoacanthoma in an 86-year-old patient was treated with intralesional b...

and efficacy of treatment in patients with LC in the course of BCLL are controversial. Many authors describe poor prognosis, when LC shows blastic transformation, known as Richter’s syndrome, and when it appears after the diagnosis of B-CLL. The potential benefit of treating only skin lesions has not been documented; however, these patients rarely stay without treatment. Numerous therapeutic mo...

Abstract Background Glucantime is the first line agent for treatment of cutaneous leishmaniasis (CL). It has adverse effects on blood elements. This research has been done to evaluate the blood complications of this medicine in patients with cutaneous leishmaniasis. Methods This clinical trial was done at Nikpour clinic, Yazd, Iran. Blood samples were collected from patients diagnosed with ...

The pretibial myxedema is a manifestation of Graves' disease characterized by accumulation of glycosaminoglycans in the reticular dermis. The dermopathy is self-limiting but in some cases may cause cosmetic and functional damage. Conventional treatment is use of topical steroids under occlusive dressing, however the intralesional application has shown good results. We present a case of pretibia...