BACKGROUND Experimental studies have demonstrated that intracoronary platelet aggregation and thrombus formation may induce marked vasoconstriction of epicardial arteries with endothelial injury. METHODS AND RESULTS To examine the effects of intracoronary thrombus formation on coronary vasomotor tone of human epicardial arteries in vivo, we studied 15 patients who developed intracoronary thro...

Myocardial regeneration utilizing novel cell-based therapies, gene transfer, and growth factors may prove to play an important role in the management of heart disease. Clinical trials have been published for a variety of biologics methods: systemic infusion, intracoronary infusion, trans venous coronary sinus, and intramyocardial. This review aims to address the recent aspects of the relationsh...

2. Hackel, D.B., Reimer, K.A., Ideker, R.E. et al. Comparison of enzymatic and anatomic estimates of myocardial infarct size in man. Circulation 1984, 70: 824-835. 3. Ogawa, H., Hiramori, K., Haze, K. et al. Comparison of clinical features of non-Q wave and Q wave myocardial infarction. Am Heart J 1986, 111: 513-518. 4. Wei, J.Y., Markis, J.E., Malagold, M. & Grossman, W. Time course of serum c...

Design of a Phase 2b Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Advanced Heart Failure The CUPID 2 Trial (Calcium Up-Regulation by Percutaneous Administration of Gene Therapy in Cardiac Disease Phase 2b) Barry Greenberg, MD,* Alex Yaroshinsky, PHD,y Krisztina M. Zsebo, PHD,z Javed Butler, MD, MPH,x G. Michael Felker, MD,k Adriaan A. Voors, MD,{ Jeffrey J. Rudy, BS,z ...

Introduction: We aimed at evaluating the clinical, laboratory and echocardiography effects of intracoronary administration of autologous bone marrow stem cell transplantation in different clinical entities of chronic Heart Failure (HF) patients.   Methods: This procedure was carried out during an interventional study conducted in the Cardiology department from JAN 2012 to APR 2013. The HF ...

BACKGROUND Adiponectin plays a protective role in the development of obesity-linked disorders. We demonstrated that adiponectin exerts beneficial actions on acute ischemic injury in mice hearts. However, the effects of adiponectin treatment in large animals and its feasibility in clinical practice have not been investigated. This study investigated the effects of intracoronary administration of...