Background—Coagulation disorders can cause intracerebral bleeding that may be difficult to detect since subsequent aberrant clot formation may mask early detection. This is an important pitfall because, when diagnosed early, bleeding in these patients is treatable. Case Description—A patient with congenital afibrinogenemia presented with recurrent hemiparesis. Spontaneous intracerebral hemorrha...

Two examples of intracerebral neurilemmoma occurred in the absence of von Recklinghausen's disease. The first case was unique because the patient was clinically asymptomatic, and the second case was unusual with a combination of oligodendroglioma and neurilemmoma in the same mass. The latter lesion arising in persons without stigmata of neurofibromatosis has not been described. The nature of ne...

Intracerebral haemorrhage as a complication of thrombolytic therapy for myocardial infarction is infrequent. but it is associated with grave prognosis. We report on a patient who had an intracerebral haemorrhage as a complication of thrombolytic treatment and advocate the CT guided free-hand removal of

In a rat model of Borna disease, intracerebral ribavirin caused clinical improvement without changes in virus titer or nucleic acid. Levels of microglia and infiltrating CD4 and CD8 cells were decreased, despite increases in mRNAs encoding interleukin-1beta (IL-1beta), IL-10, and gamma interferon in the brain. Intracerebral ribavirin may reduce morbidity through effects on microglia cell prolif...

Telomerase is a ribonucleoprotein complex that elongates telomeric DNA and appears to play an important role in cellular immortalization of cancers. Because telomerase is expressed in the vast majority of malignant gliomas but not in normal brain tissues, it is a logical target for gliomaspecific therapy. The telomerase inhibitor GRN163, a 13-mer oligonucleotide N3'-->P5' thio-phosphoramidate (...

BACKGROUND Little is known about potential ethnic differences in stroke incidence. We compared incidence and time trends of ischemic stroke and primary intracerebral hemorrhage in South Asian, Chinese and white persons in a population-based study. METHODS Population based census and administrative data analysis in the provinces of Ontario and British Columbia, Canada using validated ICD 9/ICD...

BACKGROUND AND PURPOSE The purpose of this study was to investigate time delays, adherence to guidelines, and their impact on outcomes in patients with warfarin-associated intracerebral hemorrhage transferred from community emergency departments to a comprehensive stroke center. METHODS We collected demographic, clinical, transfer time, treatment, and outcome data for patients transferred to ...

BACKGROUND AND PURPOSE Early survival of patients with intracerebral hemorrhage in general is known to be most strongly dependent on the Glasgow Coma Scale score on admission. The aim of this study was to examine the factors determining functional outcome and in-hospital mortality of patients admitted with an intracerebral hemorrhage related to oral anticoagulant (OAC) use. METHODS Correlatio...

It is almost half a century since Cushing (1903) reported the first surgical removal of an intracerebral blood clot. His report was followed six years later by a similar account by Russell and Sargent (1909). And yet, apart from sporadic but valuable reports (Penfield, 1933), the neurosurgical era of the treatment of intracerebral haemorrhages may be said only to begin with Craig and Adson's pa...

BACKGROUND AND PURPOSE Cerebral microbleeds (MBs) detected by gradient-echo MRI are considered evidence of advanced microangiopathy with potential for further bleeding. The goal of this study was to determine whether the presence of MBs is a risk factor for subsequent intracerebral hemorrhage among patients with acute ischemic stroke. METHODS We prospectively examined patients hospitalized wi...