Aberrant immune response and changes in the gut microflora are the main causes of inflammatory bowel disease (IBD). Peptidoglycan recognition proteins (Pglyrp1, Pglyrp2, Pglyrp3, and Pglyrp4) are bactericidal innate immunity proteins that maintain normal gut microbiome, protect against experimental colitis, and are associated with IBD in humans. Nucleotide-binding oligomerization domain 2 (Nod2...

was present. The decrease in microvillus length (due to the presence of microflora), expressed as a percentage of the length in axenic rat, was 5 % in the duodenum, 9 % in the jejunum and 18 % in the ileum. This was not true of microvillus diameter where only the values found for the ileum of axenic rat were significantly lower, the others not differing among themselves. In conclusion, the pres...

The function of intestinal immunity is to provide protection toward pathogens while preserving the composition of the microflora and tolerance to orally fed nutrients. This is achieved via a number of tightly regulated mechanisms including production of IgA antibodies by intestinal plasma cells. Celiac disease is a common gut disorder caused by a dysfunctional immune regulation as signified, am...

: This paper aims to analyze how intestinal flora regulates liver fibrosis pathogenesis and evaluate the regulatory effect of traditional Chinese medicine (TCM) on flora, providing new insights into treatment. Destruction microbiome can lead development, accelerating microbiome’s disruption. TCM effectively regulate helping prevent treat fibrosis. review discusses mechanisms behind changes in t...

The growth physiology of Escherichia coli during colonization of the intestinal tract was studied with four animal models: the streptomycin-treated mouse carrying a reduced microflora, the monoassociated mouse with no other microflora than the introduced strain, the conventionalized streptomycin-treated mouse, and the conventionalized monoassociated mouse harboring a full microflora. A 23S rRNA...

The article reviews the literature on relationship between intestinal microflora and cardiometabolic disorders. pathophysiological significance of disturbance in development pathology has long been known proven. However, scientific research recent decades convincingly proven that positive role microbiota is not limited only to intestines. Disturbances can affect other organs systems, particular...