The human cationic host defense peptide LL-37 has a broad range of immunomodulatory, anti-infective functions. A synthetic innate defense regulator peptide, innate defense regulator 1 (IDR-1), based conceptually on LL-37, was recently shown to selectively modulate innate immunity to protect against a wide range of bacterial infections. Using advanced proteomic techniques, ELISA, and Western blo...

Several algorithms of different domains in distributed systems are designed over the principle of the Happened-Before Relation (HBR). One common aspect among them is that they intend to be efficient in their implementation by identifying and ensuring the necessary and sufficient dependency constraints. In this pursuit, some previous works talk about the use of a transitive reduction of the caus...

Gene alterations are a well-established mechanism leading to drug resistance in acute leukemia cells. A full understanding of the mechanisms of drug resistance in these cells will facilitate more effective chemotherapy. In this study, we investigated the mechanism(s) of drug resistance in the human acute leukemia cell line MOLT-3 and its idarubicin-resistant derivative MOLT-3/IDR through comple...

Although the dependence of invertebrate photoreceptor biophysical properties on visual ecology has already been investigated in some cases, developmental aspects have largely been ignored due to the general research emphasis on holometabolous insects. Here, using the patch-clamp method, we examined changes in biophysical properties and performance of photoreceptors in the common water strider G...

OBJECTIVE Very short acquisition times and the use of low-kV protocols in CTA demand modifications in the contrast media (CM) injection regimen. The aim of this study was to optimize the use of CM delivery parameters in thoraco-abdominal CTA in a porcine model. MATERIALS AND METHODS Six pigs (55-68 kg) were examined with a dynamic CTA protocol (454 mm scan length, 2.5 s temporal resolution, 7...

Ciwidey is one of the fresh milk production areas with many tourist attractions has potential to be developed, especially in sale processed products. The four whole products produced are milk, candy, yogurt, and greek. purpose this study determine added value level profit generated from processing business superior that a priority developed Ciwidey. method used research analysis using Hayami me...

IDR(s) is a family of fast algorithms for iteratively solving large nonsymmetric linear systems. With cluster computing and in particular with Grid computing, the inner product is a bottleneck operation. In this paper, three techniques are investigated for alleviating this bottleneck. First, a recently proposed IDR(s) algorithm that is highly efficient and stable is reformulated in such a way t...

Presented is an energy-based analysis and design framework for soil structure interaction system. Theoretical formulation based on thermodynamics engineering mechanics calculating energy dissipation in structural elastic plastic finite elements presented discussed. The importance of incorporation free energy, that ensures nonnegative incremental dissipation, also known as the second law thermod...

Supporting Information Identifiability for the One-Choice Diffusion Model There is an identifiability issue in the one-choice model. The essence of the issue is that boundary setting, drift rate, and standard deviation (SD) in drift rate are highly correlated. For these parameters, different starting values for the program that fits the model to data can yield different best-fitting parameter e...

Interdisciplinary scientific research (IDR) extends and challenges the study of science on a number of fronts, including creating output science and engineering (S&E) indicators. This literature review began with a narrow search for quantitative measures of the output of IDR that could contribute to indicators, but the authors expanded the scope of the review as it became clear that differing d...