BACKGROUND/PURPOSE The etiology of meconium obstruction without cystic fibrosis is unclear. Interstitial cells of Cajal (ICC) function as pacemakers in gut motility and may play a role in the pathophysiology of the disease. METHODS The ICC were examined by immunohistochemical staining with anti-c-kit antibody in the bowel walls of 6 neonates who had meconium obstruction without cystic fibrosi...

Helicobacter pylori (HP) infection is one of the most frequent bacterial infections in humans and associated with pathogenesis gastric motility disorders such as delayed emptying (DGE). Although HP considered to delay emptying, there has been little research on underlying mechanism. Gastric involves interactions among gastrointestinal hormones, smooth muscle, enteric extrinsic autonomi...

Gastric stromal tumor (GST) is a set of gastrointestinal mesenchymal tumors those originate from interstitial cells of Cajal. Its early diagnosis and treatment are critical to prognosis.[1] The occurrence of GST remains obscure; this study used Affymetrix expression spectrum chip to detect the gene expression spectrum of GST and explore new molecular target that is used in the treatment and pro...