Aggregates of the hyperphosphorylated microtubule-associated protein tau (MAPT) are an invariant neuropathological feature of tauopathies. Here, we show that microglial neuroinflammation promotes MAPT phosphorylation and aggregation. First, lipopolysaccharide-induced microglial activation promotes hyperphosphorylation of endogenous mouse MAPT in nontransgenic mice that is further enhanced in mi...

Salmonella enteritidis lipopolysaccharide stimulates interleukin 10 (IL10) gene expression in chickens. Four genes in the IL10 cluster [polymeric immunoglobulin receptor (PIGR), interleukin 10 (IL10), map kinase-activated protein kinase 2 (MAPKAPK2), and ligatin (LGTN)] plus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase1A (DYRK1A) were investigated using the F(8) generation of ...

The stromelysin gene encodes a potent tissue-degrading proteinase whose activity is important in tissue-remoldeling processes such as wound healing, the inflammatory reaction, rheumatoid arthritis, tumor invasion, and possibly embryonic development. In light of the ability of interleukin-1 to amplify, and ability of glucocorticoids to attenuate the inflammatory response, we tested interleukin-1...

The current study examined the relationship between renal cell carcinoma-related risk and gene polymorphisms in interleukin-10, vitamin D receptor cytochrome P450 1A1 genes. Using preferred reporting items for systematic reviews meta-analyses criteria, link carcinoma was studied by utilizing Web of Science, Embase, PubMed Wanfang databases. CC TT genotypes along with interleukin-10-819C/T C-all...