The paper describes the design, implementation, and evaluation of Depot, a cloud storage system that minimizes trust assumptions. Depot tolerates buggy or malicious behavior by any number of clients or servers, yet it provides safety and liveness guarantees to correct clients. Depot provides these guarantees using a two-layer architecture. First, Depot ensures that the updates observed by corre...

Using pigmented rabbits, two fluorophotometric methods for measuring aqueous flow were compared. A corneal depot of dye was used to measure aqueous flow in one eye of each rabbit while the vitreous depot method of Johnson and Maurice was used to measure aqueous flow over the same period in the fellow eye. After intravenous administration of acetazolamide or mannitol, during the first hour after...

In this paper we provide methods for the Continuous Monitoring Problem with Inter-Depot routes (CMPID). It arises when a number of agents or vehicles have to persistently survey a set of locations. Each agent has limited energy storage (e.g., fuel tank or battery capacity) and can renew this resource at any available base station. Various realworld scenarios could be modeled with this formulati...

A new depot formulation of the LHRH analogue Zoladex (goserelin acetate) has been developed which releases the drug over a period of at least 3 months as judged by measurement of drug content in depots at intervals after insertion in male rats and by the suppression of oestrogen secretion and oestrus in female rats. This formulation is based on the lactide/glycolide polymer system used for the ...

BACKGROUND The size and geometry of an insulin depot that is formed during subcutaneous administration by an insulin pump is evaluated. A novel method is used to visualize accurately the depot formation for small volumes of insulin (of the order of 10-100 µl) at a given point in time. Conventional visualization methods such as magnetic resonance imaging are unable to provide such accurate measu...

AIMS The aim was to assess the pharmacokinetics, pharmacodynamics, safety and tolerability of octreotide subcutaneous (s.c.) depot, a novel octreotide formulation. METHODS This was a phase I, randomized, open label study. After a single dose of octreotide immediate release (IR) 200 µg, subjects were randomized to one of eight groups to receive three monthly injections of octreotide s.c. depot...

Aiming at the multi-depot heterogeneous vehicle routing problem under time-dependent road network and soft time window, considering fixed cost, window penalty cost transportation an optimization model of is established with objective minimizing distribution cost. According to characteristics problem, a hybrid genetic algorithm variable neighborhood search temporal–spatial distance designed. Cus...

Among numerous NP-hard problems, the Traveling Salesman Problem (TSP) has been one of the most explored, yet unknown one. Even a minor modification changes the problem’s status, calling for a different solution. The Generalized Traveling Salesman Problem (GTSP)expands the TSP to a much more complicated form, replacing single nodes with a group or cluster of nodes, where the objective is to fi...

AIMS AND METHOD To establish if participants with schizophrenia receiving depot antipsychotics had less insight than similar participants receiving oral atypical antipsychotics.We assessed the difference between these two groups. RESULTS Participants on oral antipsychotics had greater insight than those on depot antipsychotics (ITAQ, P=0.01). In the multiple regression analysis, only receiving ...

AIMS AND METHOD To establish if participants with schizophrenia receiving depot antipsychotics had less insight than similar participants receiving oral atypical antipsychotics.We assessed the difference between these two groups. RESULTS Participants on oral antipsychotics had greater insight than those on depot antipsychotics (ITAQ, P=0.01). In the multiple regression analysis, only receiving ...