integrins

Xiuwei H. Yang Andrea L. Richardson Maria I. Torres-Arzayus Pengcheng Zhou Chandan Sharma Alexander R. Kazarov Milena M. Andzelm Jack L. Strominger Myles Brown Martin E. Hemler

CD151, a master regulator of laminin-binding integrins (A6B4, A6B1, and A3B1), assembles these integrins into complexes called tetraspanin-enriched microdomains. CD151 protein expression is elevated in 31% of human breast cancers and is even more elevated in high-grade (40%) and estrogen receptor–negative (45%) subtypes. The latter includes triplenegative (estrogen receptor, progesterone recept...

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Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS.

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015

Elske H P Franssen Rong-Rong Zhao Hiroaki Koseki Venkateswarlu Kanamarlapudi Casper C Hoogenraad Richard Eva James W Fawcett

Integrins are adhesion and survival molecules involved in axon growth during CNS development, as well as axon regeneration after injury in the peripheral nervous system (PNS). Adult CNS axons do not regenerate after injury, partly due to a low intrinsic growth capacity. We have previously studied the role of integrins in axon growth in PNS axons; in the present study, we investigate whether int...

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