BACKGROUND Access to patient level datasets from clinical trial sponsors continues to be an important topic for the Pharmaceutical Industry as well as academic institutions and researchers. How to make access to patient level data actually happen raises many questions from the perspective of the researcher. METHODS Patient level data access models of all major pharmaceutical companies were su...

It is widely argued that countries can reap large gains from liberalizing their capital accounts if financial globalization is accompanied by the development of domestic institutions and financial markets. However, if liberalization does not lead to speedier financial development, globalization can result in adverse effects on distribution and welfare within and across countries. We use a multi...

background : computer users are exposed to work related neck disorders due to repetitive movement and static posture for prolonged period. viewing document and typing simultaneously are one of the contributing factors for neck disorders. methods : this preliminary study was conducted to evaluate the effects of the document holder on the postural neck muscles activity among computer users. nine ...

This paper presents the application of iSight for optimal tip design of complex tool holder spindle. The complex tool holder is used for holding a (milling/drilling) tool of a machine tool. The engineering problem of complex tool holder results from the twisting of spindle of tool holder. This leads to the vibration of tool holder which makes the tool holder malfunction. This engineering proble...

executive overview of the business value in harmonizing process improvement efforts when multiple improvement technologies, models and standards are in use. It proceeds with an overview of a harmonization approach that reaches from strategy to tactics and connects enterprise and discipline specific improvement. Use of any trademarks in this report is not intended in any way to infringe on the r...

This paper develops an analytical framework to study consumption and labor supply in a rich class of heterogeneous-agent economies with incomplete markets. The environment allows for trade in non-contingent and state-contingent bonds, for permanent and transitory idiosyncratic productivity shocks, and for permanent preference heterogeneity and idiosyncratic preference shocks. Exact closed-form ...

dotracheal tube and are composed of inspiratory and expiratory corrugated limbs. The two breathing tubes carry respiratory gases with volatile anesthetics to and from patients during general anesthesia. Although longer corrugated breathing tubes allow the anesthesia machine to be located farther from the patients, they are so long and flexible that they tend to hang down below the operating tab...