To the editor: The article by Yeh and colleagues is indeed interesting. The occurrence of hypokalemia was attributed to the effects of a b2-adrenergic bronchodilator on the membrane-bound sodium potassium adenosine triphosphatase pump, resulting in a skewed distribution of potassium and producing an extracellular to intracellular shift. This potassium shift resulted in thyrotoxic periodic paral...

Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic β-cells, we investigated their role in the control of insulin secretion and glucose homeostasis. In this study, we confirmed the expression of TREK-1 channels in the insulin secreting MIN6-B1 β-cel...

OBJECTIVE To describe profound hypokalemia in a comatose patient with diabetic ketoacidosis. METHODS We present a case report, review the mechanisms for the occurrence of hypokalemia in diabetic ketoacidosis, and discuss its management in the setting of hyperglycemia and hyperosmolality. RESULTS A 22-year-old woman with a history of type 1 diabetes mellitus was admitted in a comatose state....

The absence of significant losses of potassium in the urine makes dialysis-associated hyperglycemia (DH) a model for the study of the internal potassium balance. Studies of DH have revealed that hyperkalemia is frequent at presentation, insulin infusion is usually the only treatment required, and the magnitude of the decrease in serum potassium concentration (K) during treatment of DH with insu...

isolation of rat islets of langerhans was carried out by using collagenase and the destruction of exocrine tissue was performed through the injection of hanks' solution into the common bile duct. the identification of the islets was done by techniques including the use of a stereomicroscope against a black background. vital staining was done by an injection of neutral red solution through ...

Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactions are involved in the insulin secretion pathway. Insulin secretion is mediate...

Background: Hyperkalemia is a common electrolyte disorder observed in the emergency department. It often associated with underlying predisposing conditions, such as moderate or severe kidney disease, heart failure, diabetes mellitus, significant tissue trauma. Additionally, medications, inhibitors of renin-angiotensin-aldosterone system, potassium-sparing diuretics, nonsteroidal anti-inflammato...

The effects of Ahmadi continuous nursing model in children with diabetic ketoacidosis were investigated this study. A total 120 (DKA) enrolled by convenience sampling from May 2018 to February 2022. Patients equally divided into a control group and an observation random number table. received the routine model, while additionally model. indicators clinical first aid, level blood glucose, insuli...