Type 1 diabetes (T1D) is a chronic metabolic disease caused by the autoimmune destruction of insulin-producing ?-cells. Ever since 1920s, fate patients suffering from T1D was dramatically improved owing to isolation and production insulin, scientific field has largely progressed as result evidence gathered about its underpinnings mechanisms. The last years have seen this knowledge transformed i...

Nanoparticles carrying biologically active functional sets (e.g., targeting moiety, payload, tracer) have potential use in a wide range of clinical applications. Though complex, such constructions should, as far as possible, have a defined molecular architecture and be monodisperse. However, the existing methods to achieve this goal are unsuitable for the incorporation of peptides and proteins,...

The targeted delivery of therapeutic genes into specific tissues, as well as the determination of the biological fate and potential toxicity of nanoparticles, remains a highly relevant challenge for gene-based therapies. Type 1 insulin-like growth factor receptor (IGF-1R), an important oncogene, is frequently over-expressed in lung cancer and mediates cancer cell proliferation as well as tumor ...

Nanostructured metal oxide particles with diversified morphologies are in high demand nanotechnology. The particle size, shape, and overall geometry mainly depend on the fabrication method. This study reports synthesis of zinc nanoparticles (ZnO NPs) from nitrate hexahydrate [Zn(NO3)2.6H2O] precursor aqueous media at 65 °C by using lactose cow milk as a reducing agent regulating pH 6 to 10. UV–...

conclusions it seems that in people with type 2 diabetes, acute aerobic exercise can decrease the plasma levels of glucose, possibly through increasing orexin a. in addition, negative energy balance is necessary to decrease the levels of insulin and insulin resistance during acute aerobic exercise. results the analysis of findings in p ≤ 0.05 indicated that acute aerobic exercise caused a signi...