Lemieux, Andrew M., Cody J. Diehl, Julie A. Sloniger, and Erik J. Henriksen. Voluntary exercise training enhances glucose transport but not insulin signaling capacity in muscle of hypertensive TG(mREN2)27 rats. J Appl Physiol 99: 357–362, 2005. First published February 17, 2005; doi:10.1152/japplphysiol.00100.2005.— Male heterozygous TG(mREN2)27 rats (TGR) overexpress a murine renin transgene, ...

objective(s)apelin is novel adipokine acting on apj receptor, regulated by insulin and tumor necrosis factor-alpha (tnf-alpha). plasma apelin levels are increased in obese subjects. the aim of this study was to investigate whether or not the aerobic exercise modifies the elevated plasma apelin levels in obese women.materials and methodstwenty obese women (bmi 32.2 ± 6.4 kg/m2) were selected by ...

Exercise training is advocated in insulin resistance and statins are used to treat hyperlipidaemia, two cardiometabolic risk factors often presenting concurrently. Statin intake may blunt mitochondrial function and the adaptive response to exercise training. Thus combining exercise training with statin administration may have adverse effects. We examined whether improvements in cardiometabolic ...

Henriksen, Erik J. Invited Review: Effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 93: 788–796, 2002; 10.1152/japplphysiol.01219.2001.—Insulin resistance of skeletal muscle glucose transport is a key defect in the development of impaired glucose tolerance and Type 2 diabetes. It is well established that both an acute bout of exercise and chronic endurance e...

BACKGROUND Increased cardiac lipid content has been associated with diabetic cardiomyopathy. We recently showed that cardiac lipid content is reduced after 12 weeks of physical activity training in healthy overweight subjects. The beneficial effect of exercise training on cardiovascular risk is well established and the decrease in cardiac lipid content with exercise training in healthy overweig...

The purpose of this study was to determine whether the improved insulin action with short-term exercise training in middle-aged individuals is associated with enhanced phosphatidylinositol (PI) 3-kinase activity in skeletal muscle. Nine men of ages 50-70 yr were studied before and after 7 consecutive days of supervised exercise (60 min/day, 70% peak O2 consumption). Insulin sensitivity was meas...