Site-directed pharmacodelivery is a desirable but elusive goal. Endothelium and epithelium create formidable barriers to endogenous molecules as well as targeted therapies in vivo. Caveolae provide a possible, yet unproven, transcellular pathway to overcome such barriers. By using an antibody- and subfractionation-based strategy, we generated a monoclonal antibody specific for lung caveolae (TX...

introduction: the critical dependence of healthcare services systems on information along with the indigenous restriction of paper documents in satisfying this need has caused a trend toward computer information systems. the main goal of such systems is to achieve electronic health records (ehr). however, implementation of ehr in healthcare organizations is difficult and complicated. this resea...

An overview of experimental transport studies performed on the Rijnhuizen Tokamak Project (RTP) using transient transport techniques in both Ohmic and ECH dominated plasmas is presented. Modulated Electron Cyclotron Heating (ECH) and oblique pellet injection (OPI) have been used to induce electron temperature (Te) perturbations at different radial locations. These were used to probe the electro...

This study investigates the feasibility of management of aquifer recharge (MAR) in Lebanon by designing well barriers to remove seawater intrusion from the fractured carbonate aquifers. Groundwater flow and saltwater/freshwater 50% sharp interface have been modeled along the coastal area using the Ghyben-Herzberg theory. The groundwater flow simulations have been supported by field transmissivi...

BACKGROUND As the most populated Persian Gulf country, in Iran, engagement with drug injection and unsafe sex are the main routes of HIV transmission among some drug-dependent women. OBJECTIVES The current study explored the barriers that a group of drug-dependent women reported in accessing and adhering to HIV services in drug use treatment. PATIENTS AND METHODS Qualitative interviews were...

0038-1101/$ see front matter 2012 Elsevier Ltd. A http://dx.doi.org/10.1016/j.sse.2012.05.061 ⇑ Corresponding author. E-mail address: [email protected] (J. Wan). We experimentally demonstrate a field-effect transistor with a single front gate built on fully-depleted silicon-on-insulator substrate that possesses extremely steep switching slope ( 1 mV/decade) and gate-controllable hysteresis. ...

Ideally, the insulin therapy must aim at the creation of a near normal glycaemic profile without the barriers of unacceptable weight gain or hypoglycaemia. Provision of a flexible insulin regimen would further enhance adherence to the prescribed therapy and positively impact glycaemic control. Insulin degludec addresses many of the aspirations of ideal basal insulin. Long duration of action, fl...

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We analyze efficiency droop reductions in InGaN/GaN light-emitting diodes caused by a chirped AlGaN/GaN multi-quantum barrier (MQB). Such electron barriers are expected to create an additional forbidden energy range above the natural conduction band edge, which reduces the electron leakage current. Advanced numerical device simulations reveal that energy band bending practically eliminates this...