background: resistance to antiepileptic drugs as well as intolerability in 20-30% of the patients raises demand for developing new drugs with improved efficacy and safety. acceptable anticonvulsant activity, good tolerability, and inexpensiveness of docosahexaenoic acid (dha), make it as a good candidate for designing and development of the new anticonvulsant medications. methods: ten dha-based...

The bactericidal activities of four injectable antituberculosis drugs, streptomycin, amikacin, kanamycin, and capreomycin, against Mycobacterium avium and M. tuberculosis were tested. All four drugs were highly bactericidal against M. tuberculosis, with low MBC/MIC ratios and MBCs significantly lower than the maximum achievalbe concentrations in serum (Cmax). In contrast, all four drugs had ver...

INTRODUCTION Malaria ranks among the top three leading causes of morbidity and mortality in developing countries. Appropriate use of recommended antimalarial drugs is vital in the effective management of malaria. METHODOLOGY This study sought to assess the prescribing trend of antimalarial drugs at the Ghana Police Hospital. Antimalarial drug prescribing trends from 3,127 patient cards were a...

Patients with ESRD commonly experience secondary hyperparathyroidism, a condition primarily managed with activated injectable vitamin D. The biologic effects of vitamin D, however, are widespread, and it is possible that activated injectable vitamin D alters survival in ESRD. This hypothesis was tested in a historical cohort study of incident hemodialysis patients who lived throughout the Unite...

In 51 gynaecological patients the effect of an injectable salicylate (lysine acetylsalicylate 1.8 g) on postoperative pain was compared with that of morphine hydrochloride 10 mg. Both drugs were given i.m. No significant difference was found in the speed of action and degree of alleviation of pain. Nausea and vomiting were less frequent in the lysine acetylsalicylate group. This group showed a ...

Multidrug-resistant (MDR) tuberculosis (TB) (resistance to at least isoniazid and rifampicin), with >480000 cases in 2013, 10% of them being affected by extensively drug-resistant (XDR)-TB (MDR-TB with additional resistance to any fluoroquinolone, and to injectable second-line drugs (SLDs) (capreomycin, kanamycin or amikacin)), continues to represent a real threat to TB control [1–4]. In some h...

We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA40)) was observed compared with a reversible (physical gel...

Synthetic polymers have transformed society in many areas of science and technology, including recent breakthroughs in medicine. Synthetic polymers now offer unique and versatile platforms for drug delivery, as they can be "bio-tailored" for applications as implants, medical devices, and injectable polymer-drug conjugates. However, while several currently used therapeutic proteins and small mol...