A Box-Behnken design with three replicates was used for preparation and evaluation of Eudragit vancomycin (VCM) nanoparticles prepared by double emulsion. The purpose of this work was to optimize VCM nanoparticles to improve the physicochemical properties. Nanoparticles were formed by using W1/O/W2 double-emulsion solvent evaporation method using Eudragit RS as a retardant material. Full factor...

Spanules are considered one of the most advantageous drug delivery systems. Multi-drug regimen is key benefit (capsules having granules.) constructed for release API (Drug) at different rates and times. The first immediate /slow-release pattern gives an initial which followed by a constant rate extended time.This will result in constantdrugsbeing available long time period. This doses form usef...

objective(s): in this study, drug loaded electrospun nanofibrous mats were prepared and drug release and mechanism from prepared nanofibers were investigated.  materials and methods: paclitaxel (ptx) loaded polylactic acid (pla) nanofibers were prepared by electrospinning. the effects of process parameters, such as ptx concentration, tip to collector distance, voltage, temperature and flow rate...

Municipal and industrial wastewater contain a lot of contaminants. The major contaminants of concern are heavy metals. Heavy metals are known to be toxic, non-biodegradable and have a long half-life. The release of untreated wastewater containing heavy metals can cause serious problems to human, plants and animals. In this study, activated carbon was developed from sugarcane bagasse and its eff...

Prostaglandin release from microvessels isolated from the rabbit cerebral cortex was determined under three different atmospheric conditions: 100% O2 ("O2") room air, and 95% N2=5% CO2 ("N2-COj"). Initial studies with homogenates prepared from rabbit cerebral microvessels (RCMV) indicated two pathways of enzymatic PGH2 transformation, namely PGI2 synthase and GSH-dependent PGHPGE isomerase. We ...

objective: in dental treatments, use of carriers for targeted antibiotic delivery would be optimal to efficiently decrease microbial count. in this study, gentamicin was loaded into polylactic co-glycolic acid (plga) microspheres and its release pattern was evaluated for 20 days.   methods: in this experimental study, plga microspheres loaded with gentamycin were produced by the w/o/w method. t...

the influence of various polymers on the release rate of lithium carbonate from matrix-type tablets was investigated in an attempt to formulate a sustained release solid dosage form. for this purpose, tablets containing 450 mg of lithium carbonate along with various amounts of carbopol 934p, 971p, 974p, pemulen and eudragit rlpo as retarding agents and inactive ingredients (e.g. pvp, avicel or ...

the objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (ir) and modified release (mr) tablets. the experiment included rats with both normoglyceamia and streptozocin (stz)-induced hyperglyceamia. several mr formulations were designed and in vitro drug release profile was assessed by a dissolution test. for the fur...

frequent dosing of the potent anti-androgen, flutamide, is necessary to reach a therapeutic level for the treatment of prostatic carcinoma. sustained delivery of the drug could reduce the adverse effects such as gastrointestinal disorders and improve patient compliance. in the present study sustained-release matrix tablets of flutamide were prepared by direct compression method using different ...