نتایج جستجو برای: inhibitory antibodies

تعداد نتایج: 284372  

Journal: :The Journal of clinical investigation 2013
Matthew S Macauley Fabian Pfrengle Christoph Rademacher Corwin M Nycholat Andrew J Gale Annette von Drygalski James C Paulson

Antibodies confer humoral immunity but can also be harmful when they target an autoantigen, alloantigen, allergen, or biotherapeutic. New strategies are needed for antigen-specific suppression of undesired antibody responses, particularly to T cell-dependent protein antigens, because they elicit T cell help. Here we show that liposomal nanoparticles, displaying both antigen and glycan ligands o...

Journal: :Blood 1998
T L Ortel K D Moore M A Quinn-Allen T Okamura A J Sinclair J Lazarchick R Govindan F Carmagnol W H Kane

Factor V inhibitors may develop as spontaneous autoantibodies, as alloantibodies after exposure to bovine thrombin preparations, or in factor V-deficient patients after plasma therapy. Clinical manifestations range from asymptomatic laboratory abnormalities to life-threatening hemorrhage. We have characterized the anti-factor V antibodies from 12 patients diagnosed with factor V inhibitors. In ...

Journal: :Thrombosis and haemostasis 2004
Christiane Mühle Stefan Schulz-Drost Alexey V Khrenov Evgueni L Saenko Jens Klinge Holm Schneider

Clotting factor VIII (fVIII)-inhibitory antibodies represent a major problem in the treatment of haemophilia A. To understand the inactivation mechanisms and to pave the way towards modifications of recombinant clotting factors that reduce their immunogenicity, the exact localization of immunodominant epitopes is required. Here, a random peptide phage display library was employed to identify ep...

Journal: :The Journal of biological chemistry 1992
Y Oh S Matalon T R Kleyman D J Benos

An amiloride binding protein in adult rat and rabbit alveolar type II (ATII) cells was characterized using three different antibodies against epithelial Na+ channel proteins. We found that 1) polyclonal antibodies raised against epithelial Na+ channel proteins from bovine kidney cross-react with a 135-kDa protein in ATII membrane vesicles on Western blots; 2) using the photoreactive amiloride a...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
David Yin-Wei Lin Yoshimasa Tanaka Masashi Iwasaki Apostolos G Gittis Hua-Poo Su Bunzo Mikami Taku Okazaki Tasuku Honjo Nagahiro Minato David N Garboczi

Signaling through the programmed death 1 (PD-1) inhibitory receptor upon binding its ligand, PD-L1, suppresses immune responses against autoantigens and tumors and plays an important role in the maintenance of peripheral immune tolerance. Release from PD-1 inhibitory signaling revives "exhausted" virus-specific T cells in chronic viral infections. Here we present the crystal structure of murine...

Journal: :Journal of Immunology 2023

Abstract Autoimmune diseases are triggered by a critical break in peripheral tolerance, thereby allowing the immune system to target and destroy host tissues. Tolerance mechanisms, such as inhibitory receptor (IRs) on T cells, can greatly influence autoimmune disease progression outcomes, representing an opportunity for therapeutic intervention. Indeed, evidence both animal models patients sugg...

Journal: :iranian journal of public health 0
gh.h.edrissian k.montazemi a.r.nasseri a.afshar

the ifa and the blue dye decolourization g6pd tests were applied in three cross-sectional studies to find out were applied in three cross-sectional studies to find out the relationship of malarial antibodies and g6pd deficiency in the male residents of the malarious areas of southern iran. in the first study that the blood samples were collected in a random sampling method from the whole hormoz...

2016
Fredrick John Seil

Inhibitory synapses on Purkinje cell somata in organotypic cerebellar cultures derived from newborn mice were increased after chronic exposure post explantation to agents that enhance neuronal activity. Inhibitory synaptogenesis was reduced in similar cultures after continuous blockade of spontaneous neuronal discharges. By contrast, excitatory synapses developed fully in the absence of neurona...

Journal: :Acta tropica 1986
G Wiedermann O Scheiner H Kollaritsch H Hudler H Stemberger

Native normal human serum is capable of inhibiting the cytotoxic action of Entamoeba histolytica against K562 tissue culture target cells assessed by a 51Cr-release test. It is suggested that a part of the inhibitory activity on amoebae's cytotoxic action is represented by the complement system which is known to lyze trophozoites by activation of the alternative pathway. For the rest of the ser...

2015
Michelle E. Wuerth Rebecca K. Cragerud P. Clint Spiegel

Blood coagulation factor VIII is a glycoprotein cofactor that is essential for the intrinsic pathway of the blood coagulation cascade. Inhibitory antibodies arise either spontaneously or in response to therapeutic infusion of functional factor VIII into hemophilia A patients, many of which are specific to the factor VIII C2 domain. The immune response is largely parsed into "classical" and "non...

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