Valproic acid is widely used as an anti-epileptic globally. Anti-epileptic action is mediated by Gamma Amino Butyric Acid (GABA) receptors. In past and recently, several other clinical outcomes have been proposed by various studies. These under-reported clinical actions apart from anti-epileptic activity are mediated by various intracellular and extracellular pathways. Several mechanisms like H...

the effects of allopurinol, acyclovir and theophylline on the activity of adenosine deaminase (ada) were studied in 50 mm sodium phosphate buffer ph 7.5 at 27°c, using a uv– vis spectrophotometer. adenosine deaminase is inhibited by these ligands, via different types of inhibition. allopurinol, as a transition state analog of xanthine oxidase, and acyclovir competitively inhibit the catalytic a...

Background & Aim: Singhnad Guggulu is a traditional Ayurvedic formula for detoxifying and rejuvenating the joints. The present study was to investigate the α-amylase inhibition and antioxidant activities of aqueous extract of Singhnad Guggul (AESG). Experimental: α-Amylase inhibition assay by dinitro-salicylic acid method and antioxidant activity by ferric chelating and ferrous reducing assay....

The effect of vanillin on the corrosion behavior of AA6061 Al alloy in 3.5% NaCl solution wasinvestigated using potentiodynamic polarization and electrochemical noise (EN) techniques. Vanillinoffers interesting possibilities for corrosion inhibition due to its nontoxicity and high solubility inaqueous media. The best inhibition effect at 200 ppm vanillin was a marked characteristic of theinhibi...

Three consecutive alkyl esters methyl (1), ethyl (2) and isopropyl (3) were synthesized from naproxen by direct Fischer esterification reaction evaluated for their in vivo silico analgesic antiinflammatory activities. Methyl ester showed potent peripheral analgesia with 82.09% 82.59% writhing inhibition, respectively compared to that of (64.68% inhibition) at equivalent dose 25 mg/kg bw. In stu...

The aim of this study was to investigate the effect of inhibition of Marrubium astranicumleaves extract on the corrosion of carbon steel in hydrochloric acid solution by using weightloss and tafel polarization methods. Inhibition was found to increase with increasingconcentration of the leaves extract. The inhibition efficiency of this extract at an optimumconcentration of 100 mg L-1 was 99.9 %...

Effects of different carbon sources on growth and production of antifungal agent(s) by Gymnopilus spectabilis were investigated. Different carbon sources including; Glucose, fructose, lactose, maltose, manitol and sucrose at the concentration of 10 g/l and slow releasing carbon sources including malt extract and soluble starch at the concentration of 2g/l were used. Inhibition of spore germinat...

Activation-inhibition coordination is considered a dynamic process that functions as common mechanism in the synchronization and functioning of neurons, brain, behavior, their sequencing/organization, including over these different scales. The concept has broad applicability, for example, applications to maladaptivity/atypicality. Young developed hypothesis help explain efficacy right-hand reac...

In the affective sphere of EFL learning especially with regard to teaching/learning situations in Iran, one deterrent element seizes particular attention and that is inhibition self-imposed restraint on or abstinence from learning due to academic and non-academic variables such as culture, gender, psyche, extreme emotions, etc. It is related to language ego permeability hypothesis (LEPH) which ...