UNLABELLED BACKGROUND AND GOAL OF STUDY: Bispectral Index (BIS) has been used in adults to measure depth of anesthesia using various protocols. Though less investigated in children, there is growing evidence that bispectral index seems adequately calibrated for monitoring the depth of isoflurane and sevoflurane anesthesia in pediatric patients. A range of BIS scores (40-60) has been seen to be ...

Isoflurane, the most widely used inhalational anesthetic, releases inorganic fluoride during its metabolism by the cytochrome P450 system. Recent experimental data indicate that when cultured proximal tubular cells are exposed to inorganic fluoride, they become relatively resistant to myoglobin- and ATP depletion-mediated attack. The present study was undertaken to assess whether isoflurane ane...

BACKGROUND Surgical resection remains the best option for long-term survival in many solid tumors. Surgery can, however, lead to tumor cell release into the circulation. Data have suggested differential effects of anesthetic agents on cancer cell growth. This retrospective analysis investigated the association of anesthetic technique with long-term survival in patients presenting for elective s...

BACKGROUND There are a few reports regarding the comparison of these anesthetic agents, but previous studies mainly focus on the veterinary anesthesiology. Less attention has been focused comparing the effectiveness of these inhalational anesthetic agents in neurosurgery. This lack of interest is regretful particularly considering the fact that anesthetics during neurosurgery are an issue of ex...

BACKGROUND Most of what is known regarding the actions of injectable barbiturate anesthetics on the activity of lumbar sensory neurons arises from experiments performed in acute animal preparations that are exposed to invasive surgery and neural depression caused by coadministered inhalational anesthetics. Other parameters such as cortical synchronization and motor ouflow are typically not moni...

BACKGROUND We introduce a new, simple portable inhalational induction device (PD) that provides co-operative inhalational induction of anaesthesia using N(2)O and subsequent sevoflurane in the preanaesthetic induction area in children. METHODS Forty-five children (30 to 94 months old age, <35 kg) who were scheduled to undergo simple operations were assigned randomly to one of three regimens. ...

Inhalational general anesthesia results from the poorly understood interactions of haloethers with multiple protein targets, which prominently includes ion channels in the nervous system. Previously, we reported that the commonly used inhaled anesthetic sevoflurane potentiates the activity of voltage-gated K+ (Kv) channels, specifically, several mammalian Kv1 channels and the Drosophila K-Shaw2...