Under the new U.S. Environmental Protection Agency (EPA) Cancer Risk Assessment Guidelines [U.S. EPA, 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001B, March 2005], the quantitative model chosen for cancer risk assessment is based on the mode-of-action (MOA) of the chemical under consideration. In particular, the risk assessment model depends on whether or not the chemical cau...

The effects of railway operation on soil environments are an important topic. In this research, samples were collected from two diesel-driven railways and electric in Japan. A positive matrix factorization (PMF) model was applied to investigate the sources eight heavy metals near railways. results showed that dominant anthropogenic source study areas among five potential sources, with contribut...

In this study, risks for human infection associated with irrigation of municipal wastewater on short rotation willow coppice (Salix) were evaluated in three countries. The aim was also to determine the reduction of indicator organisms and pathogens in the treatment plants. Two of the field sites were chosen for further evaluation by QMRA (quantitative microbial risk assessment) applied to three...

Risk assessments of benzene have been based upon both human and animal studies. In this paper, metabolite information is used to construct an internal dose (a surrogate of the biologically effective dose) for a given administered dose. The relationship between the administered dose and this internal dose is nonlinear and is well described by a Michaelis-Menten function. The administered doses f...

The Israeli Center for Technology Assessment in Health Care (ICTAHC) was established in 1998 at the Gertner Institute for Epidemiology and Health Policy Research, on foundations set in 1992 by the Medical Technology Assessment Unit. The Center is defined as an independent multidisciplinary research center, whose main aims are to assist in developing processes for the adoption of new technologie...

Numerous studies have demonstrated that induced alkalosis through ingestion of a sodium bicarbonate (NaHCO 3 ) solution can enhance performance during maximalintensity exercise of varying durations, as well as maintain performance during high-intensity intermittent exercise. Several studies have investigated the effect of dose ingested on subsequent exercise performance. For example, Horswill e...

background: work-related musculoskeletal disorders (wmsds) are a leading cause of disability and workers compensations. objectives: the research was done in tehran pars-electric factory to prevent inducing wmsds. rapid entire body assessment (reba) was carried out to assess musculoskeletal loads on workers due to their postures, repetition, and force. nordic musculoskeletal questionnaire (nmq) ...

Hormesis, a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition, has been frequently observed in properly designed studies and is broadly generalizable as being independent of chemical/physical agent, biological model, and endpoint measured. This under-recognized and -appreciated concept has the potential to profoundly change toxicology and its r...