BACKGROUND Unfractionated heparin (UFH) has been used clinically for 5 decades. Despite being a cornerstone of anticoagulation, UFH is limited by its unpredictable pharmacokinetic profile, which makes close laboratory monitoring necessary. The most common methods for monitoring UFH are the activated partial thromboplastin time (aPTT) and antifactor Xa heparin assay (anti-Xa HA), but both presen...

by producing reactive oxygen and nitrogen species, metal-induced toxicity and carcinogenicity alter dna bases, increase  lipid peroxidation, and change calcium and sulfhydryl homeostasis. the purpose of the study was to investigate putative effects of lemon balm and cinnamomum zeylanicum on the blood markers of welding workers. we measured nickel and chromium levels, biochemical parameters, blo...

OBJECTIVES Many studies compare the efficacy of different forms of intravenous infusion sedation for critically ill patients, but little is known about the actual use of these medications. We sought to describe current use of intravenous infusion sedation in mechanically ventilated patients in U.S. intensive care units. DESIGN Retrospective cohort study of intravenous infusion sedation among ...

Abstract Intravenous (IV) anti-CD20 monoclonal antibody (mAb) therapy for chronic lymphocytic leukemia (CLL) patients often produces a first dose infusion reaction (FDIR) within the 2 h that requires careful monitoring to avoid serious complications and fatalities. To better understand FDIR, we studied blood samples collected from 37 treatment-naïve CLL in our clinical trial NCT03788291 undergo...

Objective- To evaluate the total toxic dose of lidocaine and serum lidocaine concentrations resulting in clinical signs of toxicity in chickens. Design- Experimental study Animals- Eight healthy, female, 55-week-old chickens (Lohman breed) weighing 1.45 ± 0.17 kg (mean ± SD) Procedure- A loading dose of 2% lidocaine (4 mg/kg) was administered IV, followed by a constant-rate infusion at a dose o...