Young shoots of Rubus species have been used for healing of wounds, infected insect bites and pimples in folk medicine for ages. In order to evaluate the wound healing activity of Rubus sanctus, four different extracts were prepared from the whole aerial parts of the plant by using n-hexane, chloroform, ethyl acetate and methanol, respectively. Incision wound healing model by using tensiometer ...

PVA foam has been used as a temporary skin substitute since 1977. PVA is a white, monolayered, microporous sponge. In animal experiments it was shown that cell detritus, fibrin-fur and microorganisms were taken in and kept inside the material. This effectively cleans the wound surface, the so-called “microdebridement” process. The effect is due to a strong adherence and a high capacity to absor...

mellitus of 20 years’ duration pres ented three weeks after amputation of a gangrenous big toe with a large nonhealing, infected foot wound at the surgical site. The wound had increased in size within days and had become infected despite regular professional foot care. He had been prescribed oral amoxicillin–clavulanate for 10 days, followed by oral ciprofloxacin for another 10 days. The patien...

Objective- to consider the influence of Aloe vera L fresh gel on healing process histopathologically. Design- Experimental study Animals- Five adult male mixed breed dogs aged 2-4 years Procedures- Eight symmetrical full-thickness wounds were surgically created on the back of all five dogs under general anesthesia and sterile condition. After wound creation, 1 ml fluid containing 10...

PURPOSE This study explores the potential of the simvastatin to ameliorate inflammation and infection in open infected skin wounds of rats. METHODS Fourteen Wistar rats weighing 285 +/- 12g were used. The study was done in a group whose open infected skin wounds were treated with topical application of simvastatin microemulsion (SIM, n=7) and a second group with wounds treated with saline 0.9...

Antimicrobial peptides (AMPs) are regarded as promising alternatives for antibiotics due to their inherent capacity to prevent microbial drug resistance. Amphibians are rich source of bioactive molecules, which provide numerous AMPs with various structures as drug candidates. Here, we isolated and identified a novel AMP Brevinin-2Ta (B-2Ta) from the skin secretion of the European frog, Pelophyl...

Diabetic patients often have ulcers on their lower-limbs that are infected by multiple biofilm-forming genera of bacteria, and the elimination of the biofilm has proven highly successful in resolving such wounds in patients. To that end, antimicrobial peptides have shown potential as a new anti-biofilm approach. The single human cathelicidin peptide LL-37 has been shown to have antimicrobial an...

Staphylococcus aureus is a virulent pathogen and a major causative agent of superficial and invasive skin and soft tissue infections (SSSTIs). Antibiotic resistance in S. aureus, among other bacterial pathogens, has rapidly increased, and this is placing an enormous burden on the health care sector and has serious implications for infected individuals, especially immunocompromised patients. Alt...

Pseudomonas aeruginosa has developed a complex cell-to-cell communication system that relies on low-molecular weight excreted molecules to control the production of its virulence factors. We previously characterized the transcriptional regulator MvfR, that controls a major network of acute virulence functions in P. aeruginosa through the control of its ligands, the 4-hydroxy-2-alkylquinolines (...