Screening for toxic compounds or drugs (TCD) in different body samples is one of the major tasks in clinical and forensic toxicology as well as in doping control. Several procedures using different separation and/or detection systems were used for screening purposes in the field of analytical toxicology [1]. While immunoassays allow a quick screening for a limited number of targets, chromatogra...

In order to address the field of tension between toxicology as well as basic and clinical sciences, we closely cooperate with our partner journal Archives of Toxicology. To give our readers a rapid overview of recent developments we have summarized the key messages of the most cited publications. For better orientation we grouped the articles into the categories inorganic compounds (Table 1), t...

Human and animal toxicology has had a profound impact on our historical and current understanding of air pollution health effects. Early animal toxicological studies of air pollution had distinctively military or workplace themes. With the discovery that ambient air pollution episodes led to excess illness and death, there became an emergence of toxicological studies that focused on industrial ...

Biological monitoring and biomarkers are used in occupational toxicology for a more accurate risk assessment of occupationally exposed people. Appropriate and validated biomarkers of internal dose, like urinary metabolites, besides to be positively correlated with external exposure, have a predictive value to the risk of adverse effects. The application of liquid chromatography-mass spectrometr...

Organic solvents are pervasive in the communal and industrial environments. Although many are potent central nervous system agents, clearly delineated behavioral effects have played only a minor role in the formation of exposure standards. A comprehensive behavioral pharmacology and toxicology of these compounds is one aim of US/USSR collaboration. The current report describes some actions of c...

Dichloroacetate (DCA) is a xenobiotic of interest to both environmental toxicologists and clinicians. The chemical is a product of water chlorination and of the metabolism of various drugs and industrial chemicals. Its accumulation in groundwater and at certain Superfund sites is considered a potential health hazard. However, concern about DCA toxicity is predicated mainly on data obtained in i...